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Review
. 2025 Feb;13(1):e70046.
doi: 10.1002/prp2.70046.

Part 1: Evaluation of Pediatric Cannabis-Drug Interaction Reports

Maryann R Chapin  1 , Sandra L Kane-Gill  1   2 , Xiaotong Li  1 , Kojo Abanyie  2 , Sanya B Taneja  3 , Susan Egbert  4 , Mary F Paine  5 , Richard D Boyce  1   2   3
Affiliations
Review

Part 1: Evaluation of Pediatric Cannabis-Drug Interaction Reports

Maryann R Chapin et al. Pharmacol Res Perspect. 2025 Feb.

Abstract

Data addressing safety concerns related to potential drug interactions between cannabis-derived products and pharmaceutical medications in the pediatric population are lacking. In this study, we retrieved case reports through a published literature search using PubMed and spontaneous reporting data using the Food and Drug Administration's Adverse Event Reporting System (FAERS) to identify potential cannabis- and cannabinoid-drug interactions in individuals younger than 18 years old. To evaluate the published case reports, we used the Drug Interaction Probability Scale (DIPS), a 10-item questionnaire designed to discern the causal relationship between a potential drug interaction and adverse drug reactions (ADRs). FAERS reports were deduplicated and analyzed to gather information regarding patient demographics, associated drugs, nature of the ADRs, outcomes, professions of the reporters, and reporting timelines. Seven published case reports and 9142 FAERS ADRs reports were included in the final analysis. Based on the findings, caution is warranted when cannabis or cannabinoids are used in combination with prescribed medications, including methadone, everolimus, fluoxetine, and paroxetine. Cannabinoids may inhibit drug-metabolizing enzymes, including several cytochrome P450s, leading to increased drug exposure and potentially, an increased risk for ADRs.

Keywords: adolescents; cannabidiol; cannabis; drug interactions; medication safety; natural products; pediatrics.

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Conflict of interest statement

M.R.C.: No COI/disclosures.

S.L.K.‐G. receives grant funding from the National Institute of Diabetes and Digestive and Kidney Diseases R01DK121730 and U01DK130010, the National Center for Complementary and Integrative Health and Office of Dietary Supplements (U54AT008909) and the Jewish Healthcare Foundation.

X.L.: No COI/disclosures.

S.B.T.: No COI/disclosures.

S.E.: No COI/disclosures.

M.F.P. receives grant funding from the National Center for Complementary and Integrative Health and Office of Dietary Supplements (U54AT008909), National Institute of Child Health and Human Development (R01HD081299), and National Institute of General Medical Sciences (R16GM146679). M.F.P. is a member of the Scientific Advisory Board for Simcyp, Certara UK Limited.

K.A.: No COI/disclosures.

R.D.B. receives grant funding from the National Center for Complementary and Integrative Health and Office of Dietary Supplements (U54AT008909) and the Jewish Healthcare Foundation. R.D.B. is a board member of the nonprofit CFC International.

Figures

FIGURE 1
FIGURE 1
FAERS flow diagram for inclusion of reports of cannabis– or CBD–drug interactions in pediatric patients.
See this image and copyright information in PMC

References

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