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. 2024 Oct;17(10):948-952.
doi: 10.25122/jml-2024-0287.

Gut microbiota profile and atopic dermatitis in the first year of life

Alexandru Cosmin Pantazi  1   2 , Wassan Nori  3 , Mustafa Ali Kassim Kassim  1 , Adriana Luminita Balasa  1   2 , Cristina Maria Mihai  1   2 , Tatiana Chisnoiu  1   2 , Larisia Mihai  1   2 , Adina Ungureanu  1 , Corina Elena Frecus  1   2 , Sergiu Ioachim Chirila  1 , Simona Claudia Cambrea  1
Affiliations

Gut microbiota profile and atopic dermatitis in the first year of life

Alexandru Cosmin Pantazi et al. J Med Life. 2024 Oct.

Abstract

The connection between the immune response and the composition of gut microbiota has been associated with an increased prevalence of atopic dermatitis in the first year of life. The study aimed to investigate gut microbiota characteristics in infants with atopic dermatitis compared to healthy infants to better understand the link between early-life microbiota composition and the development of atopic dermatitis. The study analyzed the intestinal microbiota of 121 infants with clinical signs of atopic dermatitis, divided into Group I (infants with atopic dermatitis) and Group II (healthy controls). The study showed that infants with atopic dermatitis presented increased values of proteolytic bacteria mainly represented by Enterobacter species (P = 0.041), Klebsiella species (P = 0.038), and Escherichia coli (P = 0.013), with significantly decreased levels of acidifying bacteria represented by Enterococcus species, Lactobacillus and Bifidobacterium (P < 0.05) and normal levels of Clostridium species, Candida albicans, Mould fungi and Geotrichum species. This study highlights distinct differences in the gut microbiota of infants with atopic dermatitis, providing insights into the dynamic intestinal ecosystem during early life for future personalized therapeutic strategies.

Keywords: acidifying bacteria; atopic dermatitis; dysbiosis; gut microbiota; infants; proteolytic bacteria.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Composition of intestinal microbiota in AD and non-AD groups
Figure 2
Figure 2
Concentration of acidifying and proteolytic bacteria according to fecal pH values
See this image and copyright information in PMC

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References

    1. Chong AC, Visitsunthorn K, Ong PY. Genetic/Environmental Contributions and Immune Dysregulation in Children with Atopic Dermatitis. J Asthma Allergy. 2022 Nov 23;15:1681–1700. doi: 10.2147/JAA.S293900. - DOI - PMC - PubMed
    1. Yang EJ, Beck KM, Sekhon S, Bhutani T, Koo J. The impact of pediatric atopic dermatitis on families: A review. Pediatr Dermatol. 2019 Jan;36(1):66–71. doi: 10.1111/pde.13727. - DOI - PubMed
    1. Ilic I, Stojkovic A, Velickovic V, Zivanovic Macuzic I, Ilic M. Atopic Dermatitis in Children Under 5: Prevalence Trends in Central, Eastern, and Western Europe. Children (Basel) 2023 Jul 25;10(8):1275. doi: 10.3390/children10081275. - DOI - PMC - PubMed
    1. Graham F, Eigenmann PA. Atopic dermatitis and its relation to food allergy. Curr Opin Allergy Clin Immunol. 2020 Jun;20(3):305–310. doi: 10.1097/ACI.0000000000000638. - DOI - PubMed
    1. Nekrasova AI, Kalashnikova IG, Bobrova MM, Korobeinikova AV, Bakoev SY, Ashniev GA, et al. Characteristics of the Gut Microbiota in regard to Atopic Dermatitis and Food Allergies of Children. Biomedicines. 2024;12(3):553. doi: 10.3390/biomedicines12030553. - DOI - PMC - PubMed

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