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. 2024 Dec 24;15(12):1520-1527.
doi: 10.5306/wjco.v15.i12.1520.

Exploring a new chapter in traditional Chinese medicine: The potential of Calculus bovis in liver cancer treatment

Huang Du  1 , Hong-Bin Chen  2 , Yu Zhao  3
Affiliations

Exploring a new chapter in traditional Chinese medicine: The potential of Calculus bovis in liver cancer treatment

Huang Du et al. World J Clin Oncol. .

Abstract

In the ongoing quest for new treatments in medicine, traditional Chinese medicine offers unique insights and potential. Recently, studies on the ability of Calculus bovis to inhibit M2-type tumour-associated macrophage polarisation by modulating the Wnt/β-catenin signalling pathway to suppress liver cancer have undoubtedly revealed new benefits and hope for this field of research. The purpose of this article is to comment on this study and explore its strengths and weaknesses, thereby providing ideas for the future treatment of liver cancer.

Keywords: Calculus bovis; Liver cancer; M2 tumor-associated macrophage polarization; The tumor microenvironment; Wnt/β-catenin pathway.

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Conflict of interest statement

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Figures

Figure 1
Figure 1
Schematic diagram of anti-liver cancer mechanism of Calculus bovis. Calculus bovis exerts its anti-liver cancer effect by inhibiting the Wnt/β-catenin pathway and suppressing the polarization of M2 tumor-associated macrophage. Citation: Huang Z, Meng FY, Lu LZ, Guo QQ, Lv CJ, Tan NH, Deng Z, Chen JY, Zhang ZS, Zou B, Long HP, Zhou Q, Tian S, Mei S, Tian XF. Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer. World J Gastroenterol 2024; 30: 3511-3533. Copyright© The Authors 2024. Published by Baishideng Publishing Group Inc. The authors have obtained the permission for figure using from the Baishideng Publishing Group.
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