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Editorial
. 2025 Feb;46(2):95-97.
doi: 10.1016/j.tips.2024.12.001. Epub 2024 Dec 24.

A novel pharmacological entity toward integrated multimodal immunotherapy

Rafael Sirera  1 , Manuel Beltrán-Visiedo  2 , Lorenzo Galluzzi  3
Affiliations
Editorial

A novel pharmacological entity toward integrated multimodal immunotherapy

Rafael Sirera et al. Trends Pharmacol Sci. 2025 Feb.

Abstract

Most solid tumors are insensitive to single-agent immunotherapy, calling for the development of combinatorial treatment regimens. Recently, Lin and collaborators developed a pharmacological platform enabling the combination of different immunotherapies into a single chemical entity. This approach may effectively circumvent obstacles associated with the simultaneous delivery of multiple immunotherapeutic agents.

Keywords: CD8(+) cytotoxic T lymphocyte; dendritic cell; immune checkpoint inhibitor; immunoevasion; multimodal targeting chimera; triple orthogonal linker.

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Conflict of interest statement

Declaration of interests L.G. is/has been holding research contracts with Lytix Biopharma, Promontory, and Onxeo, has received consulting/advisory honoraria from Boehringer Ingelheim, AstraZeneca, AbbVie, OmniSEQ, Onxeo, The Longevity Labs, Inzen, Imvax, Sotio, Promontory, Noxopharm, EduCom, and the Luke Heller TECPR2 Foundation, and holds Promontory stock options. The other authors have no conflicts of interest to declare.

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