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Review
. 2025 Feb;35(2):97-101.
doi: 10.1016/j.tcb.2024.11.011. Epub 2024 Dec 24.

Targeting the ubiquitin proteasome system in cancer stem cells

Hind Atta  1 , Dina H Kassem  2 , Mohamed M Kamal  3 , Nadia M Hamdy  4
Affiliations
Review

Targeting the ubiquitin proteasome system in cancer stem cells

Hind Atta et al. Trends Cell Biol. 2025 Feb.

Abstract

Over the past few years there has been an alarming burst of cancer burden worldwide. Cancer stem cells (CSCs) act as hidden devils within tumors, rendering cancer therapy a strenuous goal. Recently, the ubiquitin proteasome system (UPS) was proved to be an essential contributor to the CSC phenotype. This forum article aims to outline new strategies/technologies targeting UPS modulation in CSCs as a potential novel modality for efficient cancer therapy.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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