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. 2024 Dec 11:15:1472752.
doi: 10.3389/fendo.2024.1472752. eCollection 2024.

Association between thyroid hormone sensitivity and carotid plaque risk: a health examination cohort-based study

Rui Gong #  1 , Shi Wang #  2 , Hongqiong Ding  1 , Lixia Yu  1 , Ming Xu  2 , Sanping Xu  1 , Yan Ling  1
Affiliations

Association between thyroid hormone sensitivity and carotid plaque risk: a health examination cohort-based study

Rui Gong et al. Front Endocrinol (Lausanne). .

Abstract

Introduction: The involvement of thyroid hormone in cardiovascular disease remains debated. The aim of our research was to ascertain whether thyroid hormone sensitivity indices are related to carotid plaque (CAP) risk in the general population.

Methods: We recruited 5,360 participants for health examinations to explore the correlation between thyroid hormone sensitivity indices and CAP risk. We then compared baseline characteristics of participants with CAP to those without CAP based on multivariate logistic regression analysis. Additionally, we conducted subgroup analyses stratified by gender and age to further elucidate this relationship.

Results: Among the 5,360 participants, 1,055 (19.7%) were diagnosed with CAP. After adjusting for various confounding factors, our results showed a positive association between CAP risk and the indices (TFQI, PTFQI, TSHI, and TT4RI). Conversely, the FT3/FT4 ratio showed a negative correlation with CAP risk. Sex-based subgroup analysis revealed a stronger correlation between thyroid hormone sensitivity and CAP in females compared to males. In the age subgroup, the significant association was observed in older individuals (age >60) compared to middle-aged participants (age ≤60).

Conclusion: Our study suggests a significant correlation between thyroid hormone sensitivity and CAP, particularly in females and participants over the age of 60.

Keywords: carotid plaque; health examination; logistic regression; subgroup analysis; thyroid hormone sensitivity.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. We acknowledge the assistance of ChatGPT version 3.5 in improving the English expression and correcting grammatical errors in our manuscript.

Figures

Figure 1
Figure 1
Forest plots of logistic regression analysis illustrating the association between thyroid hormone sensitivity and CAP. (A) ORs for CAP across TFQI quartiles. (B) ORs for CAP across PTFQI quartiles. (C) ORs for CAP across TSHI quartiles. (D) ORs for CAP across TT4RI quartiles. (E) ORs for CAP across FT3/FT4 ratios quartiles. Adjusted for age, sex, SBP, DBP, HbA1c, TC, TG, HDL-C, and LDL-C. Q1: first quartile; Q2: second quartile; Q3: third quartile; Q4: fourth quartile. P for trend based on variable containing median value for each quartile.
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