Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov;13(11):4943-4948.
doi: 10.4103/jfmpc.jfmpc_375_24. Epub 2024 Nov 18.

The investigation of the relationship between vitamin D level and severity of diabetic ketoacidosis in new cases of type 1 diabetes in children referred to Hazrat-E- Ali-Asghar Hospital in 2021

Seyed Salaheddin Nabavi  1 , Fahimeh Soheilipour  2 , Motahare Aghajani Delavar  3 , Mahsa Javaherchian  4 , Pegah Karimian  2 , Shabahang Jafarnejad  5 , Hamidreza Khoshnezhad Ebrahimi  5 , Atoosa Mostafavi  6 , Seyedeh Mahsa Mahmoudinezhad Dezfouli  5 , Somayeh Esmaeilian  4 , Saeideh Iranmanesh  4
Affiliations

The investigation of the relationship between vitamin D level and severity of diabetic ketoacidosis in new cases of type 1 diabetes in children referred to Hazrat-E- Ali-Asghar Hospital in 2021

Seyed Salaheddin Nabavi et al. J Family Med Prim Care. 2024 Nov.

Abstract

Background and purpose: According to the role of 25-hydroxyvitamin D (25OHD) in glucose homeostasis and immune modulation, vitamin D deficiency may be associated with type 1 diabetes and diabetic ketoacidosis (DKA). Therefore, this study was conducted with the aim of investigation of the relationship between the vitamin D level and severity of diabetic ketoacidosis in new cases of type 1 diabetes in children referred to Hazrat-E-Ali-Asghar Hospital in 2021.

Methods: The present study is based on a cross-sectional study. The population studied in this research includes new cases of children with type 1 diabetes referred to Ali Asghar Children's Hospital in Tehran in 2021. The data analysis was performed using SPSS version 23 software and a significance level of less than 0.05 was considered.

Results: In total, 112 people were included in the study. The difference between the three groups of severity of ketoacidosis in blood pH and bicarbonate level was significant (P < 0.001). The comparison of serum vitamin D levels in different severity of ketoacidosis showed a significant difference between the three groups (P = 0.013), which seems to be caused by the significant difference between the severe and mild ketoacidosis groups. There was observed no significant difference between the gender subgroups and different serum vitamin D levels and also different severity of ketoacidosis (P = 0.801) and (P = 0.25).

Conclusion: Based on the findings of our study, there is a significant relationship between vitamin D and the severity of diabetic ketoacidosis in children with type 2 diabetes. We suggest that routine evaluation of vitamin D levels in diabetic patients and prescribing vitamin D supplements to patients with vitamin D deficiency to prevent the risk of diabetic ketoacidosis.

Keywords: 25-hydroxyvitamin D; children; diabetic ketoacidosis; type 1 diabetes.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Similar articles

See all similar articles

References

    1. Silverstein DC, Pruett-Saratan II A, Drobatz KJ. Measurements of microvascular perfusion in healthy anesthetized dogs using orthogonal polarization spectral imaging. J Vet Emerg Crit Care (San Antonio) 2009;19:579–87. - PubMed
    1. Bener A, Alsaied A, Al-Ali M, Al-Kubaisi A, Basha B, Abraham A, et al. High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children. Acta Diabetol. 2009;46:183–9. - PubMed
    1. Kmietowicz Z. More children showing early signs of serious diabetes complications, audit finds. BMJ. 2015;350:h1265. - PubMed
    1. Vanelli M, Chiarelli F. Treatment of diabetic ketoacidosis in children and adolescents. Acta Biomed. 2003;74:59–68. - PubMed
    1. Iqbal A, Hussain A, Iqbal A, Kumar V. Correlation between Vitamin D deficiency and diabetic ketoacidosis. Cureus. 2019;11:e4497. - PMC - PubMed

LinkOut - more resources