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. 2024 Nov;13(11):4943-4948.
doi: 10.4103/jfmpc.jfmpc_375_24. Epub 2024 Nov 18.

The investigation of the relationship between vitamin D level and severity of diabetic ketoacidosis in new cases of type 1 diabetes in children referred to Hazrat-E- Ali-Asghar Hospital in 2021

Seyed Salaheddin Nabavi  1 , Fahimeh Soheilipour  2 , Motahare Aghajani Delavar  3 , Mahsa Javaherchian  4 , Pegah Karimian  2 , Shabahang Jafarnejad  5 , Hamidreza Khoshnezhad Ebrahimi  5 , Atoosa Mostafavi  6 , Seyedeh Mahsa Mahmoudinezhad Dezfouli  5 , Somayeh Esmaeilian  4 , Saeideh Iranmanesh  4
Affiliations

The investigation of the relationship between vitamin D level and severity of diabetic ketoacidosis in new cases of type 1 diabetes in children referred to Hazrat-E- Ali-Asghar Hospital in 2021

Seyed Salaheddin Nabavi et al. J Family Med Prim Care. 2024 Nov.

Abstract

Background and purpose: According to the role of 25-hydroxyvitamin D (25OHD) in glucose homeostasis and immune modulation, vitamin D deficiency may be associated with type 1 diabetes and diabetic ketoacidosis (DKA). Therefore, this study was conducted with the aim of investigation of the relationship between the vitamin D level and severity of diabetic ketoacidosis in new cases of type 1 diabetes in children referred to Hazrat-E-Ali-Asghar Hospital in 2021.

Methods: The present study is based on a cross-sectional study. The population studied in this research includes new cases of children with type 1 diabetes referred to Ali Asghar Children's Hospital in Tehran in 2021. The data analysis was performed using SPSS version 23 software and a significance level of less than 0.05 was considered.

Results: In total, 112 people were included in the study. The difference between the three groups of severity of ketoacidosis in blood pH and bicarbonate level was significant (P < 0.001). The comparison of serum vitamin D levels in different severity of ketoacidosis showed a significant difference between the three groups (P = 0.013), which seems to be caused by the significant difference between the severe and mild ketoacidosis groups. There was observed no significant difference between the gender subgroups and different serum vitamin D levels and also different severity of ketoacidosis (P = 0.801) and (P = 0.25).

Conclusion: Based on the findings of our study, there is a significant relationship between vitamin D and the severity of diabetic ketoacidosis in children with type 2 diabetes. We suggest that routine evaluation of vitamin D levels in diabetic patients and prescribing vitamin D supplements to patients with vitamin D deficiency to prevent the risk of diabetic ketoacidosis.

Keywords: 25-hydroxyvitamin D; children; diabetic ketoacidosis; type 1 diabetes.

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Conflict of interest statement

There are no conflicts of interest.

References

    1. Silverstein DC, Pruett-Saratan II A, Drobatz KJ. Measurements of microvascular perfusion in healthy anesthetized dogs using orthogonal polarization spectral imaging. J Vet Emerg Crit Care (San Antonio) 2009;19:579–87. - PubMed
    1. Bener A, Alsaied A, Al-Ali M, Al-Kubaisi A, Basha B, Abraham A, et al. High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children. Acta Diabetol. 2009;46:183–9. - PubMed
    1. Kmietowicz Z. More children showing early signs of serious diabetes complications, audit finds. BMJ. 2015;350:h1265. - PubMed
    1. Vanelli M, Chiarelli F. Treatment of diabetic ketoacidosis in children and adolescents. Acta Biomed. 2003;74:59–68. - PubMed
    1. Iqbal A, Hussain A, Iqbal A, Kumar V. Correlation between Vitamin D deficiency and diabetic ketoacidosis. Cureus. 2019;11:e4497. - PMC - PubMed

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