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. 2024 Nov 7;12(12):10347-10356.
doi: 10.1002/fsn3.4573. eCollection 2024 Dec.

Comparative Study on the Hypoglycemic Effects of Different Parts of Musa balbisiana

Thi Ngoc Nhon Hoang  1 , Quang Liem Nguyen  1 , Thi Thanh Ngan Le  1 , Ngoc Hoa Vo  1 , Thi Anh Dao Dong  2   3 , Thi Hong Anh Le  1
Affiliations

Comparative Study on the Hypoglycemic Effects of Different Parts of Musa balbisiana

Thi Ngoc Nhon Hoang et al. Food Sci Nutr. .

Erratum in

Abstract

Diabetes mellitus is a chronic metabolic disorder that can cause elevated blood glucose levels due to impaired insulin secretion or resistance. Different parts of Musa balbisiana have been used widely in traditional medicine to treat many disorders. The present study aims to evaluate the antidiabetic ability of the corm, pseudostem, inflorescence, fruit, peel, and seed of M. balbisiana via in vitro experiments by inhibiting α-amylase and α-glucosidase enzymes as well as in vivo models on diabetic alloxan-induced mice. The results show that all investigated parts have performed potential inhibition on two investigated digestive enzymes. Seed poses the highest capacity among surveyed parts on α-amylase (IC50:f μg/mL) and α-glucosidase (IC50: 21.63 μg/mL) as well as effectively lowers the blood glucose index (IG) in alloxan-induced mice. In addition, fruit, corm, and inflorescence are considered essential parts that have high hypoglycemic effects via in vivo experiments. These findings indicate that all M. balbisiana parts are possibly a potential source for hypoglycemic agents; further clinical studies are needed to evaluate the safety of human beings before applying them in functional food and pharmaceutical industries.

Keywords: Musa balbisiana; blood glucose index; hypoglycemia; α‐amylase; α‐glucosidase.

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Conflict of interest statement

All authors have read and agreed to the published version of the manuscript. The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
α‐amylase inhibition by extracts of different parts of M. balbisiana. In each bar, different letters in the bars represent a statistically significant difference at p < 0.05 according to ANOVA analysis.
FIGURE 2
FIGURE 2
α‐glucosidase inhibition by extracts of different parts of M. balbisiana. In each bar, different letters in the bars represent a statistically significant difference at p < 0.05 according to ANOVA analysis.
FIGURE 3
FIGURE 3
Photomicrograph of a section of the pancreas of normal control at 1000 μm (A), alloxan‐induced mice without treatment at 1000 μm (B), alloxan‐induced mice treated with seed sample 300 mg/kgBW (C), 400 mg/kgBW (D), and 500 mg/kgBW (E).
See this image and copyright information in PMC

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