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Case Reports
. 2024 Nov 24;16(11):e74375.
doi: 10.7759/cureus.74375. eCollection 2024 Nov.

Mucinous Cystadenoma Arising in Post-Treatment Non-Seminomatous Germ Cell Tumor: A Rare Occurrence

Harshit Agrawal  1 , Vikas K Panwar  1 , Ankur Mittal  1 , Siddharth Saxena  1 , Ashok Singh  2
Affiliations
Case Reports

Mucinous Cystadenoma Arising in Post-Treatment Non-Seminomatous Germ Cell Tumor: A Rare Occurrence

Harshit Agrawal et al. Cureus. .

Abstract

Germ cell tumors, the most common of the testicular neoplasms, originate from primordial germ cells. These tumors are known for their totipotent nature, capable of differentiating into various cell types. This case report presents a rare occurrence of mucinous cystadenoma in a patient who received chemotherapy for metastatic left non-seminomatous germ cell tumor (NSGCT) of the testis. Despite undergoing chemotherapy, a residual retroperitoneal mass persisted. The persisting large mass is usually suggestive of teratoma or malignancy. Upon surgical removal, the histopathology revealed a surprising diagnosis: that of mucinous cystadenoma.

Keywords: mucinous tumours; retroperitoneal lymph node dissection; rplnd; testicular germ cell tumor; yolk-sac tumor.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. CT image (axial)
The red arrow indicates the residual tumor post-chemotherapy
Figure 2
Figure 2. CT image (sagittal)
The red arrow indicates the post-chemotherapy residual lesion
Figure 3
Figure 3. Surgical specimen after resection
A large 17 cm x 14 cm x 8 cm mass resected from retroperitoneum
Figure 4
Figure 4. Cut Open Specimen
The lesion consists of multiple cystic cavities filled with mucinous content
Figure 5
Figure 5. Histopathology
(a) Hematoxylin and eosin (H and E) section (100x) shows a cyst lined by columnar epithelial cells with the presence of  mucin; (b) pan-cytokeratin is strong and diffuse membranous positive; (c) SALL4 is negative; (d) SatB2 is negative
See this image and copyright information in PMC

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