Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec 11:14:1484027.
doi: 10.3389/fonc.2024.1484027. eCollection 2024.

Targeting liposarcoma: unveiling molecular pathways and therapeutic opportunities

Hongliang Liu #  1 , Xi Wang #  2 , Lingyan Liu #  3 , Bingsong Yan  4 , Fabo Qiu  1 , Bin Zhou  1
Affiliations
Review

Targeting liposarcoma: unveiling molecular pathways and therapeutic opportunities

Hongliang Liu et al. Front Oncol. .

Abstract

In recent years, an increasing number of studies have utilized molecular biology techniques to reveal important molecular heterogeneity among different subtypes of liposarcoma. Each subtype exhibits distinct genetic patterns and molecular pathways, which may serve as important targets for molecular therapy. In the present review, we focus on the molecular characteristics, molecular diagnostics, driver genes, and molecular mechanisms of liposarcoma. We also discuss the clinical research progress of related targeted therapies, with an aim to provide a reference and crucial insights for colleagues in the field.

Keywords: driver genes; liposarcoma; molecular pathogenesis; outlook; targeted therapy.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Gronchi A, Miah AB, Dei Tos AP, Abecassis N, Bajpai J, Bauer S, et al. Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆). Ann Oncol. (2021) 32:1348–65. doi: 10.1016/j.annonc.2021.07.006 - DOI - PubMed
    1. Schaefer IM, Gronchi A. WHO pathology: highlights of the 2020 sarcoma update. Surg Oncol Clin N Am. (2022) 31:321–40. doi: 10.1016/j.soc.2022.03.001 - DOI - PMC - PubMed
    1. Nacev BA, Sanchez-Vega F, Smith SA, Antonescu CR, Rosenbaum E, Shi H, et al. Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets. Nat Commun. (2022) 13:3405. doi: 10.1038/s41467-022-30453-x - DOI - PMC - PubMed
    1. Gibault L, Pérot G, Chibon F, Bonnin S, Lagarde P, Terrier P, et al. New insights in sarcoma oncogenesis: a comprehensive analysis of a large series of 160 soft tissue sarcomas with complex genomics. J Pathol. (2011) 223:64–71. doi: 10.1002/path.v223:1 - DOI - PubMed
    1. Antonescu CR. The role of genetic testing in soft tissue sarcoma. Histopathology. (2006) 48:13–21. doi: 10.1111/j.1365-2559.2005.02285.x - DOI - PubMed

LinkOut - more resources