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Editorial
. 2025 Jan 7;151(1):94-97.
doi: 10.1161/CIRCULATIONAHA.124.072263. Epub 2024 Dec 26.

Spotlight on YAP: Unlocking New Insights to Overcome the Barriers to Heart Regeneration

Nivedhitha Velayutham  1 , Richard T Lee  1   2
Affiliations
Editorial

Spotlight on YAP: Unlocking New Insights to Overcome the Barriers to Heart Regeneration

Nivedhitha Velayutham et al. Circulation. .

Abstract

This editorial refers to “Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration” by Liu et al. and “YAP Overcomes Mechanical Barriers to Induce Mitotic Rounding and Adult Cardiomyocyte Division” by Morikawa et al.

Keywords: Editorials; Hippo signaling pathway; YAP-signaling pathways; cell proliferation; myocytes, cardiac; regeneration.

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Conflict of interest statement

Dr Lee is a co-founder, scientific advisory board member, and private equity holder of Elevian, Inc, is a member of the scientific advisory board of Revidia Therapeutics, Inc., and was a past consultant to BlueRock Therapeutics. The Lee Laboratory has received past funding support from Elevian, Inc and BlueRock Therapeutics. Dr Velayutham reports no conflicts.

Figures

Figure.
Figure.. The dynamic role of YAP signaling in adult cardiomyocyte proliferation.
Schematic representation of YAP’s responsiveness to mechanical and metabolic cues in the adult heart for its control of cardiomyocyte cytoskeletal and proliferative mechanisms.
See this image and copyright information in PMC

Comment on

References

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