Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985;69(2):112-6.
doi: 10.1007/BF00293279.

Fragile sites and structural rearrangements in cancer

M De Braekeleer, B Smith, C C Lin

Fragile sites and structural rearrangements in cancer

M De Braekeleer et al. Hum Genet. 1985.

Abstract

We retracted information from a computerized databank which contains the cytogenetic findings of 17,000 patients with leukemia and lymphoma. Cytogenetic data from patients with solid tumors were compiled from Dr. Mitelman's catalogue on "Chromosome aberrations in cancer". We compared the observed distribution of breaks in chromosome bands involved in structural rearrangements with the random distribution of breaks generated by Monte Carlo simulation and showed that a majority but not all of the bands known to contain a fragile site are involved in structural aberrations in cancer and that some of them are associated with specific chromosome structural changes in specific types of cancer.

PubMed Disclaimer

References

    1. Hum Genet. 1983;63(3):299-301 - PubMed
    1. Hum Genet. 1983;64(3):273-6 - PubMed
    1. Nature. 1984 Apr 12-18;308(5960):607-8 - PubMed
    1. Hum Genet. 1977 Mar 14;35(3):269-79 - PubMed
    1. Blood. 1983 May;61(5):994-8 - PubMed

Publication types