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. 2025 Aug 7;110(9):e2985-e2993.
doi: 10.1210/clinem/dgae896.

Adrenal Venous Sampling Using Metanephrine in Primary Aldosteronism With or Without Cortisol Cosecretion

Eduardo Z Kawahara  1 , Jessica Okubo  1 , Aline C B S Cavalcante  2 , Bruna Pilan  2 , Paula Frudit  1 , Caio A A Pereira  1 , Larissa Basmage  1 , Jacqueline M Viel  1 , Ana Alice W Maciel  1 , Thais C Freitas  1   3 , Gustavo F C Fagundes  1 , Tatiana S Goldbaum  1 , Luciana P Brito  4 , Nathalia L Gomes  5   6 , Maria Adelaide A Pereira  1 , Fernando M A Coelho  7 , Felipe L Ledesma  8 , Jose L Chambo  9 , Luiz A Bortolotto  10 , Andrea Pio-Abreu  11 , Giovanio V Silva  11 , Luciano F Drager  10   11 , Maria Candida B V Fragoso  4   12 , William C Nahas  9 , Francisco C Carnevale  2 , Ana Claudia Latronico  1 , Berenice B Mendonca  4 , Madson Q Almeida  1   12
Affiliations

Adrenal Venous Sampling Using Metanephrine in Primary Aldosteronism With or Without Cortisol Cosecretion

Eduardo Z Kawahara et al. J Clin Endocrinol Metab. .

Abstract

Context: The role of plasma metanephrine in adrenal venous sampling (AVS) for assessing lateralization in primary aldosteronism (PA) requires further clarification.

Objective: To evaluate the performance of plasma metanephrine in AVS for determining aldosterone lateralization in PA, with or without mild autonomous cortisol secretion (MACS).

Methods: Sequential AVS under cosyntropin stimulation was conducted in 58 consecutive patients with PA and indication for AVS. The selectivity index (SI) was assessed using plasma metanephrine (SIMN) and cortisol (SIC). The lateralization index (LI) for aldosterone was calculated using metanephrine (LIA/MN) and cortisol (LIA/C).

Results: Right SIMN was significantly higher than left SIMN (127.91 nmol/L [78.12, 239.12] vs 46.16 nmol/L [26, 73.87]; P < .001). SIMN and SIC were strongly correlated in both the right adrenal vein (r = 0.518, P < .001) and the left adrenal vein (r = 0.435, P < .001). A SIMN > 6.45 demonstrated a sensitivity and specificity of 100%, outperforming the cut-off of 12 for identifying successful catheterization. Six cases with SIMN > 12 and SIC between 3 and 5 indicated that a SIC > 3 is sufficient for 4-confirming successful cannulation. LIA/MN and LIA/C were significantly correlated (r = 0.752, P < .001), with PA lateralization concordant in 93.1% of cases. Two discordant cases (unilateral PA by cortisol, bilateral by metanephrine) exhibited nonclassical histology, which is associated with a higher risk of PA recurrence. MACS was identified in 15 out of 58 patients (25.86%) and generally did not influence AVS lateralization, except when aldosterone and cortisol were secreted by different adrenal lesions.

Conclusion: Metanephrine was superior to cortisol after cosyntropin for assessing selectivity and equivalent to cortisol for lateralization. Moreover, MACS did not impact lateralization in AVS under cosyntropin in most cases.

Keywords: adrenal venous sampling; cortisol secretion; lateralization; metanephrine; primary aldosteronism.

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