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Review
. 2025 Dec;29(6):5085-5100.
doi: 10.1007/s11030-024-11083-5. Epub 2024 Dec 26.

Pyridazine and pyridazinone compounds in crops protection: a review

Xining Ma  1 , Ping Sun  1 , Jiaxin Wang  1 , Xinyu Huang  1 , Jian Wu  2
Affiliations
Review

Pyridazine and pyridazinone compounds in crops protection: a review

Xining Ma et al. Mol Divers. 2025 Dec.

Abstract

Pyridazine and pyridazinone belong to the same group of six-membered heterocyclic compounds, and both structurally feature two adjacent nitrogen atoms. Pyridazine and pyridazinone derivatives are frequently used as core structures in the development of new green agrochemicals due to their high activity and environmental friendliness, attracting significant attention from researchers in recent years. Over the past 20 years, significant developments have occurred in the field of pyridazine and pyridazinone derivatives, which exhibit insecticidal, fungicidal, herbicidal, antiviral, and plant growth regulating activities. Hence, summarizing the process of creating novel molecules with pyridazine and pyridazinone structures through design concepts, understanding structure-activity relationships, and mechanisms of action is an important undertaking. This review aims to provide a comprehensive overview of these advancements, shedding light on the discovery and mechanism of action of novel pesticides in the pyridazine and pyridazinone categories.

Keywords: Innovation of pesticide; Pesticide; Pyridazine; Pyridazinone.

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Conflict of interest statement

Declarations. Competing Interests: The authors declare that they have no competing interests.

References

    1. El-Helw EA, Hosni EM, Kamal M, Hashem AI, Ramadan SK (2024) Synthesis, insecticidal activity, and molecular docking analysis of some benzo [h] quinoline derivatives against Culex pipiens L. Larvae Bioorg Chem 150:107591. https://doi.org/10.1016/j.bioorg.2024.107591 - DOI - PubMed
    1. Ramadan SK, El-Helw EA (2018) Synthesis and antimicrobial activity evaluation of some novel heterocycles derived from chromonyl-2 (3 H)-furanone. J Chem Res 42:332–336. https://doi.org/10.3184/174751918X15295796734379 - DOI
    1. Akhtar W, Shaquiquzzaman M, Akhter M, Verma G, Khan MF, Alam MM (2016) The therapeutic journey of pyridazinone. Eur J Med Chem 123:256–281. https://doi.org/10.1016/j.ejmech.2016.07.061 - DOI - PubMed
    1. Pattison G, Sandford G, Yufit DS, Howard JA, Christopher JA, Miller DD (2009) Polysubstituted pyridazinones from sequential nucleophilic substitution reactions of tetrafluoropyridazine. J Org Chem 74:5533–5540. https://doi.org/10.1021/jo9006943 - DOI - PubMed
    1. Matsuda K, Arima K, Akiyama S, Yamada Y, Abe Y, Suenaga H, Hashimoto J, Shin-ya K, Nishiyama M, Wakimoto T (2022) A natural dihydropyridazinone scaffold generated from a unique substrate for a hydrazine-forming enzyme. J Am Chem Soc 144:12954–12960. https://doi.org/10.1021/jacs.2c05269 - DOI - PubMed

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