Negative Valence in Obsessive-Compulsive Disorder: A Worldwide Mega-Analysis of Task-Based Functional Neuroimaging Data of the ENIGMA-OCD Consortium

Nadza Dzinalija¹, Chris Vriend², Lea Waller³, H Blair Simpson⁴, Iliyan Ivanov⁵, Sri Mahavir Agarwal⁶, Pino Alonso⁷, Lea L Backhausen⁸, Srinivas Balachander⁹, Aniek Broekhuizen¹⁰, Miguel Castelo-Branco¹¹, Ana Daniela Costa¹², Hailun Cui¹³, Damiaan Denys¹⁴, Isabel Catarina Duarte¹⁵, Goi Khia Eng¹⁶, Susanne Erk³, Sophie M D D Fitzsimmons², Jonathan Ipser¹⁷, Fern Jaspers-Fayer¹⁸, Niels T de Joode², Minah Kim¹⁹, Kathrin Koch²⁰, Jun Soo Kwon²¹, Wieke van Leeuwen²², Christine Lochner²³, Hein J F van Marle²⁴, Ignacio Martinez-Zalacain²⁵, Jose M Menchon²⁶, Pedro Morgado¹², Janardhanan C Narayanaswamy²⁷, Ian S Olivier¹⁷, Maria Picó-Pérez²⁸, Tjardo S Postma²⁹, Daniela Rodriguez-Manrique²⁰, Veit Roessner⁸, Oana Georgiana Rus-Oswald³⁰, Venkataram Shivakumar⁹, Carles Soriano-Mas³¹, Emily R Stern³², S Evelyn Stewart¹⁸, Anouk L van der Straten³³, Bomin Sun³⁴, Sophia I Thomopoulos³⁵, Dick J Veltman³⁶, Nora C Vetter³⁷, Henny Visser³⁸, Valerie Voon³⁹, Henrik Walter³, Ysbrand D van der Werf⁴⁰, Guido van Wingen¹⁴; ENIGMA-OCD Consortium; Dan J Stein⁴⁶, Paul M Thompson³⁵, Ilya M Veer⁴⁷, Odile A van den Heuvel²

Collaborators, Affiliations

Collaborators

ENIGMA-OCD Consortium:
Sara Bertolin⁷, Nicole Beyer⁸, Joao Castelhano¹⁵, Sunah Choi⁴¹, Beatriz Couto⁴², Eva Real⁴³, Cinto Segalas⁴³, Nuno Sousa⁴⁴, Anne Uhlmann⁸, Yijie Zhao⁴⁵

Affiliations

¹ Department of Anatomy & Neurosciences, Amsterdam University Medical Center, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Compulsivity, Impulsivity and Attention, Amsterdam University Medical Center, Amsterdam, the Netherlands. Electronic address: n.dzinalija@amsterdamumc.nl.
² Department of Anatomy & Neurosciences, Amsterdam University Medical Center, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Compulsivity, Impulsivity and Attention, Amsterdam University Medical Center, Amsterdam, the Netherlands.
³ Department of Psychiatry and Neurosciences, Charité Campus Mitte, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
⁴ Columbia University Irving Medical College, Columbia University, New York, New York; Center for Obsessive-Compulsive Disorder and Related Disorders, New York State Psychiatric Institute, New York, New York.
⁵ Icahn School of Medicine at Mount Sinai, New York, New York.
⁶ Department of Psychiatry, Obsessive-Compulsive Disorder Clinic, National Institute of Mental Health and Neurosciences, Bangalore, India; Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
⁷ Department of Psychiatry, The Institute of Biomedical Research of Bellvitge, Barcelona, Spain; Department of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica En Red de Salud Mental, Carlos III Health Institute, Madrid, Spain.
⁸ Department of Child and Adolescent Psychiatry, Faculty of Medicine of the Technische Universität Dresden, Dresden, Germany.
⁹ Department of Psychiatry, Obsessive-Compulsive Disorder Clinic, National Institute of Mental Health and Neurosciences, Bangalore, India.
¹⁰ Department of Anatomy & Neurosciences, Amsterdam University Medical Center, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Compulsivity, Impulsivity and Attention, Amsterdam University Medical Center, Amsterdam, the Netherlands; Mental Healthcare Institute Geestelijke Gezondheidszorg Centraal, Amersfoort, the Netherlands.
¹¹ Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
¹² Clinical Academic Center of Braga, Braga, Portugal; Clinical Academic Center of Braga, Braga, Portugal.
¹³ Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
¹⁴ Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands.
¹⁵ Coimbra Institute for Biomedical Imaging and Translational Research, Instituto de Ciências Nucleares Aplicadas à Saúde, University of Coimbra, Coimbra, Portugal.
¹⁶ Department of Psychiatry, New York University Grossman School of Medicine, New York, New York; Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York.
¹⁷ Department of Psychiatry and Mental Health, Brain Behaviour Unit, University of Cape Town, Cape Town, South Africa; Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
¹⁸ Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
¹⁹ Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
²⁰ Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany.
²¹ Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea.
²² Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Arkin Mental Health Care, Amsterdam, the Netherlands.
²³ South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
²⁴ Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Mental Healthcare Institute Geestelijke Gezondheidszorg inGeest Mental Health Care, Amsterdam, the Netherlands.
²⁵ Department of Psychiatry, The Institute of Biomedical Research of Bellvitge, Barcelona, Spain; Department of Radiology, Hospital Universitari de Bellvitge, Barcelona, Spain.
²⁶ Department of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; Department of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica En Red de Salud Mental, Carlos III Health Institute, Madrid, Spain.
²⁷ Department of Psychiatry, Obsessive-Compulsive Disorder Clinic, National Institute of Mental Health and Neurosciences, Bangalore, India; Faculty of Health, School of Medicine, Deakin University, Geelong, Victoria, Australia; Goulburn Valley Health, Shepparton, Victoria, Australia.
²⁸ Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal; Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castellón de la Plana, Spain.
²⁹ Department of Anatomy & Neurosciences, Amsterdam University Medical Center, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Compulsivity, Impulsivity and Attention, Amsterdam University Medical Center, Amsterdam, the Netherlands; Mental Healthcare Institute Geestelijke Gezondheidszorg inGeest Mental Health Care, Amsterdam, the Netherlands.
³⁰ Department of Clinical Psychology, Leiden University, Leiden, the Netherlands.
³¹ Department of Psychiatry, The Institute of Biomedical Research of Bellvitge, Barcelona, Spain; Centro de Investigación Biomédica En Red de Salud Mental, Carlos III Health Institute, Madrid, Spain; Department of Social Psychology and Quantitative Psychology, Institute of Neurociences, University of Barcelona, Barcelona, Spain.
³² Department of Psychiatry, New York University Grossman School of Medicine, New York, New York; Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York; Neuroscience Institute, New York University Grossman School of Medicine, New York, New York.
³³ Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Levvel, Academic Center for Child and Adolescent Psychiatry and Specialized Youth Care, Amsterdam, the Netherlands.
³⁴ Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³⁵ Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California.
³⁶ Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Compulsivity, Impulsivity and Attention, Amsterdam University Medical Center, Amsterdam, the Netherlands.
³⁷ Department of Child and Adolescent Psychiatry, Faculty of Medicine of the Technische Universität Dresden, Dresden, Germany; Department of Psychology, Medical School Berlin, Berlin, Germany.
³⁸ Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands.
³⁹ Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Fudan University, Shanghai, China.
⁴⁰ Department of Anatomy & Neurosciences, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Compulsivity, Impulsivity and Attention, Amsterdam University Medical Center, Amsterdam, the Netherlands.
⁴¹ Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea.
⁴² Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal.
⁴³ Department of Psychiatry, The Institute of Biomedical Research of Bellvitge, Barcelona, Spain; Centro de Investigación Biomédica En Red de Salud Mental, Carlos III Health Institute, Madrid, Spain.
⁴⁴ Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal; Clinical Academic Center of Braga, Braga, Portugal.
⁴⁵ Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, China; Fudan University, Shanghai, China.
⁴⁶ Neuroscience Institute, University of Cape Town, Cape Town, South Africa; South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
⁴⁷ Compulsivity, Impulsivity and Attention, Amsterdam University Medical Center, Amsterdam, the Netherlands; Department of Developmental Psychology, University of Amsterdam, Amsterdam, the Netherlands.

PMID: 39725297
DOI: 10.1016/j.biopsych.2024.12.011

Meta-Analysis

Negative Valence in Obsessive-Compulsive Disorder: A Worldwide Mega-Analysis of Task-Based Functional Neuroimaging Data of the ENIGMA-OCD Consortium

Nadza Dzinalija et al. Biol Psychiatry. 2025.

. 2025 Aug 1;98(3):219-229.

doi: 10.1016/j.biopsych.2024.12.011. Epub 2024 Dec 24.

Authors

Collaborators

ENIGMA-OCD Consortium:
Sara Bertolin⁷, Nicole Beyer⁸, Joao Castelhano¹⁵, Sunah Choi⁴¹, Beatriz Couto⁴², Eva Real⁴³, Cinto Segalas⁴³, Nuno Sousa⁴⁴, Anne Uhlmann⁸, Yijie Zhao⁴⁵

Affiliations

¹ Department of Anatomy & Neurosciences, Amsterdam University Medical Center, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Compulsivity, Impulsivity and Attention, Amsterdam University Medical Center, Amsterdam, the Netherlands. Electronic address: n.dzinalija@amsterdamumc.nl.
² Department of Anatomy & Neurosciences, Amsterdam University Medical Center, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Compulsivity, Impulsivity and Attention, Amsterdam University Medical Center, Amsterdam, the Netherlands.
³ Department of Psychiatry and Neurosciences, Charité Campus Mitte, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
⁴ Columbia University Irving Medical College, Columbia University, New York, New York; Center for Obsessive-Compulsive Disorder and Related Disorders, New York State Psychiatric Institute, New York, New York.
⁵ Icahn School of Medicine at Mount Sinai, New York, New York.
⁶ Department of Psychiatry, Obsessive-Compulsive Disorder Clinic, National Institute of Mental Health and Neurosciences, Bangalore, India; Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
⁷ Department of Psychiatry, The Institute of Biomedical Research of Bellvitge, Barcelona, Spain; Department of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica En Red de Salud Mental, Carlos III Health Institute, Madrid, Spain.
⁸ Department of Child and Adolescent Psychiatry, Faculty of Medicine of the Technische Universität Dresden, Dresden, Germany.
⁹ Department of Psychiatry, Obsessive-Compulsive Disorder Clinic, National Institute of Mental Health and Neurosciences, Bangalore, India.
¹⁰ Department of Anatomy & Neurosciences, Amsterdam University Medical Center, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Compulsivity, Impulsivity and Attention, Amsterdam University Medical Center, Amsterdam, the Netherlands; Mental Healthcare Institute Geestelijke Gezondheidszorg Centraal, Amersfoort, the Netherlands.
¹¹ Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
¹² Clinical Academic Center of Braga, Braga, Portugal; Clinical Academic Center of Braga, Braga, Portugal.
¹³ Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
¹⁴ Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands.
¹⁵ Coimbra Institute for Biomedical Imaging and Translational Research, Instituto de Ciências Nucleares Aplicadas à Saúde, University of Coimbra, Coimbra, Portugal.
¹⁶ Department of Psychiatry, New York University Grossman School of Medicine, New York, New York; Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York.
¹⁷ Department of Psychiatry and Mental Health, Brain Behaviour Unit, University of Cape Town, Cape Town, South Africa; Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
¹⁸ Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
¹⁹ Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
²⁰ Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany.
²¹ Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea; Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea.
²² Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Arkin Mental Health Care, Amsterdam, the Netherlands.
²³ South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
²⁴ Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Mental Healthcare Institute Geestelijke Gezondheidszorg inGeest Mental Health Care, Amsterdam, the Netherlands.
²⁵ Department of Psychiatry, The Institute of Biomedical Research of Bellvitge, Barcelona, Spain; Department of Radiology, Hospital Universitari de Bellvitge, Barcelona, Spain.
²⁶ Department of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; Department of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica En Red de Salud Mental, Carlos III Health Institute, Madrid, Spain.
²⁷ Department of Psychiatry, Obsessive-Compulsive Disorder Clinic, National Institute of Mental Health and Neurosciences, Bangalore, India; Faculty of Health, School of Medicine, Deakin University, Geelong, Victoria, Australia; Goulburn Valley Health, Shepparton, Victoria, Australia.
²⁸ Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal; Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castellón de la Plana, Spain.
²⁹ Department of Anatomy & Neurosciences, Amsterdam University Medical Center, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Compulsivity, Impulsivity and Attention, Amsterdam University Medical Center, Amsterdam, the Netherlands; Mental Healthcare Institute Geestelijke Gezondheidszorg inGeest Mental Health Care, Amsterdam, the Netherlands.
³⁰ Department of Clinical Psychology, Leiden University, Leiden, the Netherlands.
³¹ Department of Psychiatry, The Institute of Biomedical Research of Bellvitge, Barcelona, Spain; Centro de Investigación Biomédica En Red de Salud Mental, Carlos III Health Institute, Madrid, Spain; Department of Social Psychology and Quantitative Psychology, Institute of Neurociences, University of Barcelona, Barcelona, Spain.
³² Department of Psychiatry, New York University Grossman School of Medicine, New York, New York; Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York; Neuroscience Institute, New York University Grossman School of Medicine, New York, New York.
³³ Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Levvel, Academic Center for Child and Adolescent Psychiatry and Specialized Youth Care, Amsterdam, the Netherlands.
³⁴ Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³⁵ Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California.
³⁶ Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Compulsivity, Impulsivity and Attention, Amsterdam University Medical Center, Amsterdam, the Netherlands.
³⁷ Department of Child and Adolescent Psychiatry, Faculty of Medicine of the Technische Universität Dresden, Dresden, Germany; Department of Psychology, Medical School Berlin, Berlin, Germany.
³⁸ Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, the Netherlands.
³⁹ Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Fudan University, Shanghai, China.
⁴⁰ Department of Anatomy & Neurosciences, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam, the Netherlands; Compulsivity, Impulsivity and Attention, Amsterdam University Medical Center, Amsterdam, the Netherlands.
⁴¹ Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, South Korea.
⁴² Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal.
⁴³ Department of Psychiatry, The Institute of Biomedical Research of Bellvitge, Barcelona, Spain; Centro de Investigación Biomédica En Red de Salud Mental, Carlos III Health Institute, Madrid, Spain.
⁴⁴ Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal; Clinical Academic Center of Braga, Braga, Portugal.
⁴⁵ Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University, Shanghai, China; Fudan University, Shanghai, China.
⁴⁶ Neuroscience Institute, University of Cape Town, Cape Town, South Africa; South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.
⁴⁷ Compulsivity, Impulsivity and Attention, Amsterdam University Medical Center, Amsterdam, the Netherlands; Department of Developmental Psychology, University of Amsterdam, Amsterdam, the Netherlands.

PMID: 39725297
DOI: 10.1016/j.biopsych.2024.12.011

Abstract

Objective: Obsessive-compulsive disorder (OCD) is associated with altered brain function related to processing of negative emotions. To investigate neural correlates of negative valence in OCD, we pooled functional magnetic resonance imaging data of 633 individuals with OCD and 453 healthy control participants from 16 studies using different negatively valenced tasks across the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium's OCD Working Group.

Methods: Participant data were processed uniformly using HALFpipe, to extract voxelwise participant-level statistical images of one common first-level contrast: negative versus neutral stimuli. In preregistered analyses, parameter estimates were entered into Bayesian multilevel models to examine whole-brain and regional effects of OCD and its clinically relevant features-symptom severity, age of onset, and medication status.

Results: We provided a proof of concept that participant-level data can be combined across several task paradigms and observed one common task activation pattern across individuals with OCD and control participants that encompasses frontolimbic and visual areas implicated in negative valence. Compared with control participants, individuals with OCD showed very strong evidence of weaker activation of the bilateral occipital cortex (P+ < 0.001) and adjacent visual processing regions during negative valence processing that was related to greater OCD severity, late onset of the disorder, and an unmedicated status. Individuals with OCD also showed stronger activation in the orbitofrontal, subgenual anterior cingulate, and ventromedial prefrontal cortex (all P+ < 0.1) that was related to greater OCD severity and late onset.

Conclusions: In the first mega-analysis of this kind, we replicated previous findings of stronger ventral prefrontal activation in OCD during negative valence processing and highlight the lateral occipital cortex as an important region implicated in altered negative valence processing.

Keywords: Clinical features; Disorder effects; Mega-analysis; Negative valence; Obsessive-compulsive disorder; Task-based fMRI.

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Negative Valence in Obsessive-Compulsive Disorder: A Worldwide Mega-Analysis of Task-Based Functional Neuroimaging Data of the ENIGMA-OCD Consortium

Collaborators

Affiliations

Negative Valence in Obsessive-Compulsive Disorder: A Worldwide Mega-Analysis of Task-Based Functional Neuroimaging Data of the ENIGMA-OCD Consortium

Authors

Collaborators

Affiliations

Abstract

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MeSH terms

LinkOut - more resources

Medical

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