Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec 27;37(1):7.
doi: 10.1007/s40520-024-02897-2.

Association between social engagement decline and cognitive function changes: mediating effect of depressive symptoms

Ping Ni  1 , Hongxiu Chen  1 , Xiuying Hu  2
Affiliations

Association between social engagement decline and cognitive function changes: mediating effect of depressive symptoms

Ping Ni et al. Aging Clin Exp Res. .

Abstract

Background: Cognitive decline is a significant public health problem worldwide, but little is known about social engagement's impact on cognitive changes over time. This study aimed to explore the relationship between social engagement decline and cognitive function change in Chinese adults, and to analyze the effect of changes in depressive symptoms on this relationship.

Methods: Participants were selected from the China Health and Retirement Longitudinal Study. Multiple linear regression was conducted to determine the association between social engagement decline and cognitive function changes, and a three-step method was used to test the mediating role of changes in depressive symptoms.

Results: During the four-year follow-up, participants' overall cognitive function decreased by an average of 0.41 points (3.0%). The decline in social engagement was significantly associated with subsequent poorer global cognitive function (Model 1: β = - 0.060, P =.005; Model 2: β = - 0.056, P =.009), and changes in depressive symptoms partially mediated this effect, accounting for 15.3% of the total effect in Model 1 and 13.8% in Model 2. Model 1 adjusted for sociodemographic characteristics, and Model 2 adjusted for health-related factors based on Model 1.

Conclusion: When developing programs for cognitive improvement in middle-aged and older adults, measures to enhance social engagement should be considered. This may not only reduce depressive symptoms but also help to minimize cognitive decline.

Keywords: CHARLS; Cognitive decline; Depressive symptoms; Older adults; Social engagement.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: The data were collected from the CHARLS, which was approved and organized by Peking University’s Institutional Review Board (IRB00001052-11015). All participants provided their written informed consent before they completed the survey. All procedures were conducted according to the relevant guidelines and regulations. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Comparison of cognitive function scores in 2011 and 2015
Fig. 2
Fig. 2
Changes in depressive symptoms examined as mediators of the association between SE decline and changes in global cognitive function in Model 1. X: SE decline. Y: Change in global cognitive function. M: Change in depressive symptoms
See this image and copyright information in PMC

References

    1. World Health Organization (2024) Ageing. https://www.who.int/health-topics/ageing. Accessed 8 May 2024
    1. Zeng Y, Feng Q, Hesketh T et al (2017) Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study. Lancet 389:1619–1629. 10.1016/S0140-6736(17)30548-2 - DOI - PMC - PubMed
    1. Visser PJ, Scheltens P, Verhey FRJ (2005) Do MCI criteria in drug trials accurately identify subjects with predementia Alzheimer’s disease? J Neurol Neurosurg Psychiatry 76:1348–1354. 10.1136/jnnp.2004.047720 - DOI - PMC - PubMed
    1. GBD 2019 Dementia Forecasting Collaborators (2022) Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of Disease Study 2019. Lancet Public Health 7:e105–e125. 10.1016/S2468-2667(21)00249-8 - DOI - PMC - PubMed
    1. World Health Organization (2023) Dementia. https://www.who.int/news-room/fact-sheets/detail/dementia. Accessed 8 May 2024

LinkOut - more resources