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Case Reports
. 2024 Nov 25;16(11):e74450.
doi: 10.7759/cureus.74450. eCollection 2024 Nov.

The Recurrence of Tracheobronchial Papillomatosis Following Prostate Cancer Diagnosis

Tilemahos Iakovakis  1 , Fotios Drakopanagiotakis  1 , Efterpi Tirikidou  1 , Alexandra Giatromanolaki  2 , Mary Kouroupi  2 , Vasiliki E Georgakopoulou  3 , Paschalis Steiropoulos  1
Affiliations
Case Reports

The Recurrence of Tracheobronchial Papillomatosis Following Prostate Cancer Diagnosis

Tilemahos Iakovakis et al. Cureus. .

Abstract

Recurrent respiratory papillomatosis (RRP) is a challenging disease to manage, due to its highly recurring nature and the lack of a definitive treatment. It is characterized by the presence of benign papillomatous lesions caused by the human papillomavirus (HPV), which can pose a threat to the patient's airway patency and restrict their breathing ability. We present the case of a 64-year-old patient with a history of papillomas in the trachea and bronchi, treated with endobronchial cryotherapy. However, tracheal and bronchial papillomas recurred 10 years after the initial treatment and two years after the diagnosis of prostate cancer and hormonal therapy. We also engage in a discussion of the clinical and radiological features of RRP.

Keywords: biopsy; bronchoscopy; cough; prostate cancer; recurrent respiratory papillomatosis.

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Conflict of interest statement

Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Chest CT (lung window)
The image showed papillomas (black arrow) on the left wall of the trachea and significant emphysema in the lung parenchyma CT: computed tomography
Figure 2
Figure 2. Chest CT (mediastinal window)
The image showed papillomas (white arrow) in the right bronchus CT: computed tomography
Figure 3
Figure 3. Bronchoscopic examination
A: Papillomatous lesions of the trachea (black arrow). B) Papillomatous lesions of the right main bronchus (black arrow)
Figure 4
Figure 4. Histological examination of specimens obtained by bronchoscopy
Immunohistochemistry revealed p16 (+)
See this image and copyright information in PMC

References

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