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. 2024 Dec 12:12:1482177.
doi: 10.3389/fpubh.2024.1482177. eCollection 2024.

Geographical variation in high-impact chronic pain and psychological associations at the regional level: a multilevel analysis of a large-scale internet-based cross-sectional survey

Kenta Wakaizumi  1   2 , Chisato Tanaka  1   2 , Yuta Shinohara  1   2 , Yihuan Wu  1   2 , Saki Takaoka  1   2 , Morihiko Kawate  1   2 , Hiroyuki Oka  3 , Ko Matsudaira  4
Affiliations

Geographical variation in high-impact chronic pain and psychological associations at the regional level: a multilevel analysis of a large-scale internet-based cross-sectional survey

Kenta Wakaizumi et al. Front Public Health. .

Abstract

Background: A geographical analysis could be employed to uncover social risk factors and interventions linked to chronic pain. Nonetheless, geographical variation in chronic pain across different regions of Japan have not been well explored. This study aims to investigate geographical variation in high-impact chronic pain (HICP), defined as moderate to severe chronic pain, and examine the associated psychological factors at the prefecture level.

Methods: A cross-sectional Internet-based survey involving 52,353 participants was conducted to assess chronic pain conditions, stress levels, mood states, educational levels, living status, regions, sleep duration, and exercise habits. A geographical analysis evaluated the prevalence of HICP at the prefecture level, and a multilevel analysis explored the risk factors for HICP at both individual and prefecture levels.

Results: The geographical analysis revealed that Fukushima exhibited the highest HICP prevalence (23.2%; z-score = 2.11), Oita ranked second (23.0%; z-score = 2.00), and Okinawa showed the lowest prevalence (14.9%; z-score = -2.45). Geographical maps of Japan indicated that regional-level subjective stress, negative emotions, and short sleep were associated with higher HICP prevalence. In contrast, positive emotions, such as vigor, were associated with lower prevalence. Multilevel analysis revealed a significant improvement in model fit after incorporating psychological factors at the prefecture level (p < 0.001) and identified significant associations between high subjective stress and low vigor at the prefecture level with HICP prevalence (p < 0.001).

Conclusion: There are regional differences in HICP prevalence, and at the prefecture level, subjective stress and vigor are associated with HICP.

Keywords: geographical variation; high impact chronic pain; multilevel analysis; profile of mood states; subjective stress.

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Conflict of interest statement

KM reports receiving grants and personal fees from AYUMI Pharmaceutical Corporation, Nippon Zoki Pharmaceutical Co., Ltd., Ono Pharmaceutical Co., Ltd, Shionogi Co., Ltd., Eli Lilly Japan, Astellas Pharma Inc., Toto Ltd., Eisai Co., Ltd., Teijin Pharma Limited, Japan Inc., and Hisamitsu Pharmaceutical Co., Inc.; personal fees from Pfizer Inc., Janssen Pharmaceutical K.K., Kaken Pharmaceutical Co., Ltd., Mochida Pharmaceutical Co., Ltd., and Daiichi Sankyo Company, Limited; grants from Sompo Holdings, Inc., MTG, NuVasive Japan, and Murata Manufacturing Co., Ltd.; grants from Okamura Corporation; and non-financial support from Trunk Solution Co., Ltd. outside the submitted work. HO received grants from Teijin Pharma Limited, grants from Pfizer Inc., grants from Fujifilm Medical Co., Ltd., grants and personal fees from AYUMI Pharmaceutical Corporation, Nippon Zoki Pharmaceutical Co., Ltd., Ono Pharmaceutical Co., Ltd., Sompo Holdings, Inc., NuVasive Japan, and grants from Eli Lilly Japan. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Japanese heat maps representing regional variation in high-impact chronic pain (HICP) and pain-related factors among 47 prefectures. Values are adjusted for age and sex. N, north.
Figure 2
Figure 2
Standardized prevalence rate of high-impact chronic pain (HICP) and short sleep, and scores of subjective stress, depression-dejection, fatigue, anger-hostility, and vigor of each prefecture in Japan. Prefectures with the top and bottom 10 prevalence rates of HICP are presented, with the order sorted by the rate. The z-scores in this figure were computed to compare how much the prevalence differed from the average in each region. A score of 0 represents the average, positive scores represent higher-than-average prevalence, and negative ones indicate lower-than-average prevalence. Values greater than 2 or less than −2 were considered significant, and we shaded the z–score area from −2 to 2 as a non-significant value.
See this image and copyright information in PMC

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