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. 2024 Dec 12:14:1507157.
doi: 10.3389/fonc.2024.1507157. eCollection 2024.

Current research trends and hotspots of boron neutron capture therapy: a bibliometric and visualization analysis

Yuyang Cong  1 , Muyasha Abulimiti  2 , Yoshitaka Matsumoto  2 , Jing Jin  1   3
Affiliations

Current research trends and hotspots of boron neutron capture therapy: a bibliometric and visualization analysis

Yuyang Cong et al. Front Oncol. .

Abstract

Purpose: This study aimed to describe the trends, current hotspots, and future directions in boron neutron capture therapy (BNCT) through a bibliometric analysis.

Methods: Articles related to BNCT published before 2023-12-31 were retrieved from the Web of Science Core Collection database. VOSviewer, R, and CiteSpace were used for bibliometric analysis and visualization.

Results: A total of 3347 related publications from 1975 to 2023 were retrieved. Since a burst of published documents in 1992, the past three decades have witnessed continuous investigations into BNCT-related studies. Japan was the most productive country (794, 23.72%), followed by the USA (792, 23.66%), while the latter had the most citations. Kyoto University was the most influential institution. Ono K was the most prolific author, and Applied Radiation and Isotopes was the most popular journal. Ono K was the author that had the most total citations, followed by Barth RF. "Carborane", "boronophenylalanine", "glioblastoma", "sodium borocaptate", "cancer" and "drug delivery" were the most frequent keywords. The article "Dendrimers and dendritic polymers in drug delivery" had the most citations, whereas "Boron delivery agents for neutron capture therapy of cancer" had the highest outbreak value.

Conclusion: Over the past three decades, research on BNCT has expanded significantly, with the development of novel boron carriers with improved medicinal characteristics being the most extensively investigated area. Future research will likely focus on the validation and modification of current BNCT treatment modalities using conventional boron agents in brain tumors, accelerator-based neutron sources and the application of BNCT in more clinical scenarios.

Keywords: CiteSpace; VOSviewer; bibliometric analysis; boron neutron capture therapy; research trends.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Ideal instance of BNCT.
Figure 2
Figure 2
Research process of this study.
Figure 3
Figure 3
(A) Annual publications related to BNCT research. (B) Cumulative publications related to BNCT research. (C) Annual citations of the publications related to BNCT research. (D) Annual h-index of BNCT publications.
Figure 4
Figure 4
(A) Coauthorship overlay of countries/regions. (B) Geographic distribution of BNCT publications and cooperation strengths. (C) Coauthorship overlay of institutions. (D) Coauthorship overlay of authors. (E) Three fields plot of authors, affiliations and countries/regions.
Figure 5
Figure 5
(A) Cocitation network map of journals. (B) Keyword co-occurrence network diagram of BNCT. (C) The trending topics. (D) Eight representative clusters of keyword clusters from 2019 to 2023.
Figure 6
Figure 6
(A) The top 25 keywords and (B) references with the strongest citation bursts.
Figure 7
Figure 7
The production of top 5 (A) countries, (B) authors, (C) affiliations, and (D) journals over time.
See this image and copyright information in PMC

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