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Review
. 2024 Nov 27;16(4):752-768.
doi: 10.3390/hematolrep16040072.

The Role of 11C-Methionine PET Imaging for the Evaluation of Lymphomas: A Systematic Review

Francesco Dondi  1 , Maria Gazzilli  2 , Gian Luca Viganò  3 , Antonio Rosario Pisani  4 , Cristina Ferrari  4 , Giuseppe Rubini  4 , Francesco Bertagna  1
Affiliations
Review

The Role of 11C-Methionine PET Imaging for the Evaluation of Lymphomas: A Systematic Review

Francesco Dondi et al. Hematol Rep. .

Abstract

Background: In the last years, different evidence has underlined a possible role for [11C]-methionine ([11C]MET) positron emission tomography (PET) imaging for the evaluation of lymphomas. The aim of this paper was, therefore, to review the available scientific literature focusing on this topic. Methods: A wide literature search of the PubMed/MEDLINE, Scopus and Cochrane Library databases was conducted in order to find relevant published articles investigating the role of [11C]MET in the assessment of lymphomas. Results: Eighteen studies were included in the systematic review and the main fields of application of this imaging modality were the evaluation of disease, therapy response assessment, prognostic evaluation and differential diagnosis with other pathological conditions. Conclusion: Even with heterogeneous evidence, a possible role for [11C]MET PET imaging in the assessment of lymphomas affecting both the whole body and the central nervous system was underlined. When compared to [18F]fluorodesoxyglucose ([18F]FDG) imaging, in general, similar results have been reported between the two modalities in these settings.

Keywords: 11C-methionine; DLBCL; PET; PET/CT; central nervous system; lymphoma; positron emission tomography.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of the research of eligible studies evaluating the role of [11C]MET PET imaging in the assessment of lymphomas.
Figure 2
Figure 2
QUADAS-2 quality assessment for risk of bias and applicability concerns for the studies considered in the review.
See this image and copyright information in PMC

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