Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Dec 2;10(12):833.
doi: 10.3390/jof10120833.

Structures and Biological Activities of Secondary Metabolites from Daldinia spp

Miao Yu  1   2 , Shiji Chen  1   2 , Jueying Shi  1   2 , Weikang Chen  1   2 , Yikang Qiu  1   2 , Jing Lan  1   2 , Shiyan Qu  1   2 , Jiayi Feng  1   2 , Ru Wang  1   2 , Fangru Lin  1   2 , Guolei Huang  1   2 , Caijuan Zheng  1   2
Affiliations
Review

Structures and Biological Activities of Secondary Metabolites from Daldinia spp

Miao Yu et al. J Fungi (Basel). .

Abstract

The genus Daldinia have long been recognized as a source of structural novel, pharmaceutically relevant natural products. We reviewed the structures and activities of secondary metabolites isolated from the genus of Daldinia from January 1995 to June 2024, and 280 compounds, including six major categories-terpenoids, alkaloids, polyketides, polyphenols, steroids, and other classes-are presented in this review. Among these metabolites, 196 were identified as new structures. Remarkably, 112 compounds exhibited a range of biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, anti-virus, and enzyme-inhibitory activities. This review highlights the bioactive metabolites discovered in the past three decades from the genus of Daldinia while also exploring the potential of these symbiotic fungi as rich sources of novel and diverse natural products. The varying bioactivities of these metabolites offer a vast array of promising lead compounds and also could significantly contribute to the development of new medicines.

Keywords: Daldinia sp.; bioactivity; secondary metabolites.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 3
Figure 3
Cytochalasins produced by Daldinia species (22–45).
Figure 4
Figure 4
Indole alkaloids produced by Daldinia species (46–70).
Scheme 1
Scheme 1
The putative biosynthetic pathways of 46 and 47 [27].
Scheme 2
Scheme 2
Synthesis of 62 and 64 [32].
Scheme 3
Scheme 3
Synthesis of 67 [32].
Figure 5
Figure 5
Other alkaloids produced by Daldinia species (71–74).
Scheme 4
Scheme 4
Putative biogenetic pathway for 74 [16].
Figure 14
Figure 14
Other classes produced by Daldinia species (264–280).
Figure 1
Figure 1
The images of (a–c) of Daldinia spp. (a): Daldinia concentrica; (b,c): Daldinia eschscholtzii.
Figure 2
Figure 2
Terpenoids produced by Daldinia species (1–21).
Scheme 5
Scheme 5
Putative biosynthetic pathway of compounds 75–77 [36].
Scheme 6
Scheme 6
Putative biosynthetic pathway of compounds 78–79 [37].
Figure 6
Figure 6
Xanthones produced by Daldinia species (75–79).
Figure 7
Figure 7
Chromones produced by Daldinia species (80–114).
Figure 7
Figure 7
Chromones produced by Daldinia species (80–114).
Figure 8
Figure 8
Lactones produced by Daldinia species (115–144).
Figure 8
Figure 8
Lactones produced by Daldinia species (115–144).
Figure 9
Figure 9
Naphthalenone derivatives produced by Daldinia species (145–171).
Figure 10
Figure 10
Other polyketides produced by Daldinia species (172–199).
Scheme 7
Scheme 7
Putative biosynthetic pathway of polyketides (116, 171, 197–198) [50].
Figure 11
Figure 11
Naphthols produced by Daldinia species (200–228).
Figure 11
Figure 11
Naphthols produced by Daldinia species (200–228).
Scheme 8
Scheme 8
Putative biosynthetic pathway of (±) galewone (213–214) [60].
Figure 12
Figure 12
Phenolics produced by Daldinia species (229–257).
Figure 13
Figure 13
Steroids produced by Daldinia species (258–263).
Figure 15
Figure 15
Structural diversity (left) and bioactivities (right) of compounds isolated from Daldinia sp. that were discovered from January 1995 to June 2024.
Figure 16
Figure 16
Biological activities of secondary metabolites isolated from Daldinia sp.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Zheng R.H., Li S.J., Zhang X., Zhao C.Q. Biological activities of some new secondary metabolites isolated from endophytic fungi: A review study. Int. J. Mol. Sci. 2021;22:959. doi: 10.3390/ijms22020959. - DOI - PMC - PubMed
    1. Kong D.W., Niu R.C., Mao Y.Z., Liu L.L. Research progress on active metabolites of endophytes. Heilongjiang Agric. Sci. 2019;12:151–154.
    1. Wethalawe A.N., Alwis Y.V., Udukala D.N., Paranagama P.A. Antimicrobial compounds isolated from endolichenic fungi: A review. Molecules. 2021;26:3901. doi: 10.3390/molecules26133901. - DOI - PMC - PubMed
    1. Kellogg J.J., Raja H.A. Endolichenic fungi: A new source of rich bioactive secondary metabolites on the horizon. Phytochem. Rev. 2017;16:271–293. doi: 10.1007/s11101-016-9473-1. - DOI
    1. Gupta S., Chaturvedi P., Kulkarni M.G., Staden J.V. A critical review on exploiting the pharmaceutical potential of plant endophytic fungi. Biotechnol. Adv. 2020;39:107462. doi: 10.1016/j.biotechadv.2019.107462. - DOI - PubMed

LinkOut - more resources