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Observational Study
. 2025 Feb 1;73(2):261-266.
doi: 10.4103/IJO.IJO_110_24. Epub 2024 Dec 27.

Ocular adnexal lymphoma - A single-center observational study of survival outcomes

Karuvel Kannan Saraswathi  1   2 , Pragya Saini  3 , Radhakrishnan Santhi  4 , Veerappan Muthukkaruppan  5 , Ayyasamy Vanniarajan  1   2 , Usha Kim  3
Affiliations
Observational Study

Ocular adnexal lymphoma - A single-center observational study of survival outcomes

Karuvel Kannan Saraswathi et al. Indian J Ophthalmol. .

Abstract

Purpose: This study aims to comprehensively characterize the clinical, demographic, and histopathological features of ocular adnexal lymphoma (OAL) and assess their impact on patients' survival outcomes.

Methods: A total of 123 patients were included in the study; of these, 93 patients were selected for survival analysis. Survival data were analyzed using the Kaplan-Meier test, and correlation was assessed through the log-rank test and Cox regression analysis.

Results: The median age at presentation was 56 years. Furthermore, 98% of patients had primary OAL. The orbit was the most common site of involvement. The majority of patients were of B-cell origin (98%), and only 2% of patients had T-cell lymphoma. In addition, 83% of patients were treated with chemotherapy, and with a median follow-up of 38 months, complete remission was achieved in 48% of patients. The median progression-free survival was 26.4 months. The presence of disseminated disease was strongly linked to an unfavorable prognosis ( P < 0.001) and reduced survival ( P = 0.037).

Conclusion: The 5-year overall survival of the entire study cohort was 81%. The prognosis for OAL is found to be favorable, but the presence of dissemination serves as a notable predictor for poor prognosis.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Representative clinical and histopathologic features in ocular adnexal lymphoma patients: (a) Axial proptosis in a 57-year-old OAL patient; (b) *MRI image revealed an isointense mass lesion in intra and extraconal compartment of left orbit with encasement of optic nerve sheath complex and extrinsic proptosis; (c) Hematoxylin-Eosin (H and E) staining shows small-sized monomorphic atypical lymphoid cells; (d) H and E staining shows of large B-cell type OAL (e, f) Tumor cells expressing CD20 (B-cell marker) and CD3 (T-cell marker: scattered positivity) exhibit typical characteristics consistent with non-Hodgkin’s B-cell lymphoma
Figure 2
Figure 2
Disease-specific survival is associated with disease dissemination in ocular adnexal lymphoma. Patients without dissemination showed more favorable disease-specific survival than the disseminated OAL (P = 0.037)
See this image and copyright information in PMC

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