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. 1985;109(1):5-8.
doi: 10.1007/BF01884247.

Selective induction of nasal cavity tumors in rats by diallylnitrosamine

P M Pour, C J Grandjean, S Knepper

Selective induction of nasal cavity tumors in rats by diallylnitrosamine

P M Pour et al. J Cancer Res Clin Oncol. 1985.

Abstract

Weekly intragastric administration of 20, 40, and 80 mg/kg body weight diallylnitrosamine to BD IX rats selectively induced nasal and paranasal cavity tumors with incidences of 30%, 85%, and 65% in females and of 0%, 75%, and 80% in males, respectively. All tumors were carcinomas of the olfactory region, and 95% were invasive. Only a few papillomas in the anterior region were found simultaneously with the carcinomas.

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