Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985;109(1):5-8.
doi: 10.1007/BF01884247.

Selective induction of nasal cavity tumors in rats by diallylnitrosamine

P M Pour, C J Grandjean, S Knepper

Selective induction of nasal cavity tumors in rats by diallylnitrosamine

P M Pour et al. J Cancer Res Clin Oncol. 1985.

Abstract

Weekly intragastric administration of 20, 40, and 80 mg/kg body weight diallylnitrosamine to BD IX rats selectively induced nasal and paranasal cavity tumors with incidences of 30%, 85%, and 65% in females and of 0%, 75%, and 80% in males, respectively. All tumors were carcinomas of the olfactory region, and 95% were invasive. Only a few papillomas in the anterior region were found simultaneously with the carcinomas.

PubMed Disclaimer

References

    1. Althoff J, Grandjean C, Gold B (1977) Diallylnitrosamine: A potent respiratory carcinogen in Syrian golden hamsters; Brief communication. J Natl Cancer Inst 59:1569–1571 - PubMed
    1. Cardesa A, Pour PM, Haas H, Althoff J, Mohr U (1976) Histogenesis of tumors from the nasal cavities induced by diethylnitrosamine. Cancer 37:346–355 - PubMed
    1. Druckrey H, Preussman R, Ivankovic S, Schmähl D (1967) Organtrope Wirkung bei 65 verschiedenenN-Nitrosoverbindungen in BD-Ratten. Z Krebsforsch 69:103–201 - PubMed
    1. Montesano R, Bresil H, Drevon C, Piccoli C (1982) DNA repair in mammalian cells exposed to multiple doses of alkylating agents. Biochimie 64:591–594 - PubMed
    1. Pour PM, Cardesa A, Althoff J, Mohr U (1974) Tumorigenesis in the nasal olfactory region of Syrian golden hamsters. The effect of di-n-propyl-nitrosamine and related compounds. Cancer Res 34:16–26 - PubMed

Publication types

LinkOut - more resources