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Review
. 2025 Mar;132(3):331-339.
doi: 10.1007/s00702-024-02875-y. Epub 2024 Dec 27.

The centenarian blueprint: lessons in defying Parkinson's disease

Roongroj Bhidayasiri  1   2   3 , Ikuko Aiba  4 , Masahiro Nomoto  5
Affiliations
Review

The centenarian blueprint: lessons in defying Parkinson's disease

Roongroj Bhidayasiri et al. J Neural Transm (Vienna). 2025 Mar.

Erratum in

Abstract

Recent advancements in neurology have shifted focus from mere diagnosis to comprehensive management of movement disorders, particularly Parkinson's Disease (PD), which is rapidly increasing in prevalence due to global ageing trends. While age is a key risk factor for PD, centenarians often exhibit a remarkably low prevalence of the disease, presenting an intriguing paradox. This viewpoint explores potential reasons for this low prevalence, drawing on studies from regions with high centenarian populations, known as Blue Zones. The authors highlight the importance of genetic, lifestyle, and environmental factors in promoting healthy ageing and examines how these may contribute to the resilience against PD found in centenarians. By understanding the protective mechanisms in centenarians, particularly the concept of hormesis and factors like diet, exercise, and social connections, we may inform prevention strategies for PD. The study proposes the "EAT, MOVE, SLEEP, PROTECT, and REPEAT" approach as a framework for lifestyle interventions to counteract PD risk factors. Ultimately, centenarians offer valuable insights into delaying neurodegeneration, providing a model for potential preventive trials for PD.

Keywords: Ageing; Centenarians; Parkinson’s disease; Parkinson’s disease prevention; Supercentenarians.

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Conflict of interest statement

Declarations. Conflicts of interest: The authors declare no conflicts of interest.

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References

    1. Andersen-Ranberg K, Schroll M, Jeune B (2001) Healthy centenarians do not exist, but autonomous centenarians do: a population-based study of morbidity among Danish centenarians. J Am Geriatr Soc 49(7):900–908. https://doi.org/10.1046/j.1532-5415.2001.49180.x
    1. Andersen SL, Sebastiani P, Dworkis DA, Feldman L, Perls TT (2012) Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span. J Gerontol Biol Sci Med Sci 67(4):395–405. https://doi.org/10.1093/gerona/glr223 - DOI
    1. Arai Y, Sasaki T, Hirose N (2017) Demographic, phenotypic, and genetic characteristics of centenarians in Okinawa and Honshu, Japan: part 2 Honshu, Japan. Mech Ageing Dev 165(Pt B):80–85. https://doi.org/10.1016/j.mad.2017.02.005 - DOI - PubMed
    1. Bastos PAD, Barbosa R (2022) Motor reserve: how to build neuronal resilience against ageing and neurodegeneration? Rev Neurol (Paris) 178(8):845–854. https://doi.org/10.1016/j.neurol.2021.12.012 - DOI - PubMed
    1. Belvisi D, Pellicciari R, Fabbrini G, Tinazzi M, Berardelli A, Defazio G (2020) Modifiable risk and protective factors in disease development, progression and clinical subtypes of Parkinson’s disease: what do prospective studies suggest? Neurobiol Dis 134:104671. https://doi.org/10.1016/j.nbd.2019.104671 - DOI - PubMed

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