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. 2025 Mar-Apr:142-143:108989.
doi: 10.1016/j.nucmedbio.2024.108989. Epub 2024 Dec 17.

Solid phase extraction chromatography-based radiochemical isolation of cyclotron-produced 51Mn from enriched 54Fe targets

Kendall E Barrett  1 , Jason C Mixdorf  1 , Johan Svedjehed  2 , Jeanine Batterton  3 , Jennifer Eagleburger  3 , Yongjun Yan  3 , Katherine Gagnon  2 , Eduardo Aluicio-Sarduy  1 , Todd E Barnhart  1 , Jonathan W Engle  4
Affiliations

Solid phase extraction chromatography-based radiochemical isolation of cyclotron-produced 51Mn from enriched 54Fe targets

Kendall E Barrett et al. Nucl Med Biol. 2025 Mar-Apr.

Abstract

We report DGA extraction chromatography isolation of 51Mn from isotopically enriched 54Fe. The method has been studied in semi-automated and automated realizations. The former achieves a decay corrected radiochemical yield of 78 ± 1 % (n = 3) and a separation factor of (1.0 ± 0.8) x 105 (n = 3). With GE HealthCare's Solid Target Platform (STP) and FASTlab the latter, fully automated method achieves a decay corrected radiochemical yield of 87 ± 1 % (n = 3) and a separation factor of (2.7 ± 0.9) x 104 (n = 3). Both setups efficiently isolate cyclotron-produced 51MnCl2 suitable for human administration as determined by developed Chemistry, Manufacturing, and Controls (CMC) acceptance criteria, and support exploration of 51Mn as a clinical diagnostic tool.

Keywords: Manganese-51; Radionuclide production; Solid phase extraction chromatography.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests.

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