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Review
. 2025 May;30(3):477-491.
doi: 10.1007/s10741-024-10478-8. Epub 2024 Dec 27.

Epicardial adipose tissue: a new link between type 2 diabetes and heart failure-a comprehensive review

Si-Jia Zhang #  1 , Si-Wei Wang #  2   3 , Shi-Yu Liu  1 , Ping Li  1 , De-Lian Huang  1 , Xi-Xi Zeng  2 , Tian Lan  2   3 , Ye-Ping Ruan  1   4 , Hai-Jiao Shi  5 , Xin Zhang  6   7
Affiliations
Review

Epicardial adipose tissue: a new link between type 2 diabetes and heart failure-a comprehensive review

Si-Jia Zhang et al. Heart Fail Rev. 2025 May.

Abstract

Diabetic cardiomyopathy is a unique cardiomyopathy that is common in diabetic patients, and it is also a diabetic complication for which no effective treatment is currently available. Moreover, relevant studies have revealed that a link exists between type 2 diabetes and heart failure and that abnormal thickening of EAT is inextricably linked to the development of diabetic heart failure. Numerous clinical studies have demonstrated that EAT is implicated in the pathophysiologic process of diabetic myocardial disease. In this overview, we will introduce the physiology, pathophysiology of the disease and potential therapeutic strategies, knowledge gaps, and future directions of the role of epicardial adipose tissue in type 2 diabetes mellitus and heart failure to promote the development of novel therapeutic approaches to improve the prognosis of patients with diabetic cardiomyopathy.

Keywords: Diabetic cardiomyopathy; Epicardial adipose tissue; Heart failure; Type 2 diabetes.

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Conflict of interest statement

Declarations. Conflict of interest: The authors declare no competing interests.

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