Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 May;263(5):1405-1415.
doi: 10.1007/s00417-024-06726-0. Epub 2024 Dec 27.

Implications of optic disc rotation in the visual field progression of myopic open-angle glaucoma

Pei-Ning Tu  1   2   3 , Chih-Heng Hung  1   2 , Yi-Chun Chen  4   5
Affiliations

Implications of optic disc rotation in the visual field progression of myopic open-angle glaucoma

Pei-Ning Tu et al. Graefes Arch Clin Exp Ophthalmol. 2025 May.

Abstract

Purpose: To investigate the relationship between the characteristics of optic disc rotation and visual field (VF) progression in patients with myopic open-angle glaucoma (OAG).

Methods: We included 53 eyes from 53 myopic OAG patients who were followed-up over a 3-year period. The characteristics of optic disc rotation including the degree of optic disc rotation, direction of optic disc rotation, and optic disc rotation-VF defect correspondence were investigated. The rates of global and regional VF progression were compared with different characteristics of optic disc rotation.

Results: Thirty-seven eyes (69.8%) showed inferior optic disc rotation and 41 (77.4%) eyes showed optic disc rotation-VF defect correspondence. The inferiorly rotated optic discs with corresponding superior VF defect had faster VF progression in the superior peripheral region (P = 0.028) and superiorly rotated optic discs with corresponding inferior VF defect had faster VF progression in the inferior peripheral region (P = 0.031). The VF progression was restricted to the superior hemifield in the eyes with inferiorly rotated optic discs and corresponding superior VF defects.

Conclusion: In myopic OAG patients, the direction of optic disc rotation might predict faster VF progression in the corresponding peripheral region.

Keywords: Myopia; Optic disc rotation; Primary open-angle glaucoma; Visual field.

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflict of interest: No Conflicts of Interest. Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the Cathay General Hospital and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent: Informed consent was considered not required by Institutional Review Board of the Cathay General Hospital and all data were fully de-identified before accessing them.

Figures

Fig. 1
Fig. 1
Measurements of optic disc tilt, optic disc rotation, and β-PPA. Optic disc tilt was determined by the tilt ratio, defined as the ratio between the longest diameter and shortest diameter of the optic disc. b Optic disc rotation was defined as the deviation of the longest diameter of the disc from the vertical meridian, which was a vertical line perpendicular to a reference line connecting the fovea and the center of the disc. The angle between the vertical meridian and the longest diameter of the disc was termed the degree of rotation. c β-PPA was defined as an inner crescent of chorioretinal atrophy with visible sclera and choroidal vessels
Fig. 2
Fig. 2
The representative case showed a 49-year-old female with myopia OAG followed up from 2007 to 2012. Fundus photographs of the right eye showed tilted and inferiorly rotated disc (rotation degree: 5.06) with DHs. The faster VF progression was found in the superior peripheral region
See this image and copyright information in PMC

References

    1. Holden BA, Fricke TR, Wilson DA, Jong M, Naidoo KS, Sankaridurg P et al (2016) Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050. Ophthalmology 123(5):1036–1042. 10.1016/j.ophtha.2016.01.006 - PubMed
    1. Ding BY, Shih YF, Lin LLK, Hsiao CK, Wang IJ (2017) Myopia among schoolchildren in east Asia and Singapore. Surv Ophthalmol 62(5):677–697. 10.1016/j.survophthal.2017.03.006 - PubMed
    1. Tsai TH, Liu YL, Ma IH, Su CC, Lin CW, Lin LL et al (2021) Evolution of the Prevalence of Myopia among Taiwanese Schoolchildren: A Review of Survey Data from 1983 through 2017. Ophthalmology 128(2):290–301. 10.1016/j.ophtha.2020.07.017 - PubMed
    1. Mitchell P, Hourihan F, Sandbach J, Wang JJ (1999) The relationship between glaucoma and myopia: the Blue Mountains Eye Study. Ophthalmology 106(10):2010–2015. 10.1016/s0161-6420(99)90416-5 - PubMed
    1. Xu L, Wang Y, Wang S, Wang Y, Jonas JB (2007) High myopia and glaucoma susceptibility the Beijing Eye Study. Ophthalmology 114(2):216–220. 10.1016/j.ophtha.2006.06.050 - PubMed

MeSH terms

LinkOut - more resources