Immunotherapy or targeted therapy with or without stereotactic radiosurgery for patients with brain metastases from melanoma or non-small cell lung cancer - The ETOP 19-21 USZ-STRIKE study

Michael Weller¹, Emilie Le Rhun², Lydia Tsamtsouri³, Reinhard Dummer⁴, Matthias Guckenberger⁵, Karin Ribi⁶, Anna Maria di Giacomo⁷, Gabriele Minuti⁸, Ana Collazo-Lorduy⁹, Dieta Brandsma¹⁰, Mary O'Brien¹¹, Ekin Ermis¹², Natalie Fischer¹³, Paolo Ascierto¹⁴, Mario Mandala¹⁵, Giuseppe Minniti¹⁶, Patricia Iranzo¹⁷, Heidi Roschitzki-Voser⁶, Barbara Ruepp⁶, Eva Grolimund⁶, Urania Dafni¹⁸, Solange Peters¹⁹, Rolf Stahel⁶; ETOP 19-21 USZ-STRIKE collaborators

Affiliations

¹ University Hospital Zürich, Department of Neurology, Zürich, Switzerland.
² University Hospital Zürich, Department of Medical Oncology and Hematology, Zürich, Switzerland.
³ ETOP Statistical Office, Frontier-Science Foundation Hellas, Athens, Greece.
⁴ University Hospital Zürich, Department of Dermatology, Zürich, Switzerland.
⁵ University Hospital Zürich, Department of Radiation Oncology, Zürich, Switzerland.
⁶ Coordinating Center, ETOP IBCSG Partners Foundation, Bern, Switzerland.
⁷ University of Siena, Center for Immuno-Oncology, University Hospital of Siena, Italy.
⁸ Clinical Trial Unit: Phase 1 and Precision Medicine, IRCCS, National Cancer Institute, Regina Elena, Rome, Italy.
⁹ Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.
¹⁰ Netherlands Cancer Institute, Amsterdam, the Netherlands.
¹¹ Royal Marsden Hospital, London, UK.
¹² Department of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
¹³ Kantonsspital Winterthur, Switzerland.
¹⁴ Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy.
¹⁵ University of Perugia, Medical Oncology Unit, Santa Maria Misericordia Hospital, Perugia, Italy.
¹⁶ Policlinico Umberto 1, Rome, Italy.
¹⁷ Vall d'Hebron Hospital Campus and Institute of Oncology (VHIO), Barcelona, Spain.
¹⁸ ETOP Statistical Office, Frontier-Science Foundation Hellas, Athens, Greece; National and Kapodistrian University of Athens, Athens, Greece.
¹⁹ CHUV, Lausanne, Switzerland.

PMID: 39731865
DOI: 10.1016/j.lungcan.2024.108069

Free article

Review

Immunotherapy or targeted therapy with or without stereotactic radiosurgery for patients with brain metastases from melanoma or non-small cell lung cancer - The ETOP 19-21 USZ-STRIKE study

Michael Weller et al. Lung Cancer. 2025 Jan.

Free article

. 2025 Jan:199:108069.

doi: 10.1016/j.lungcan.2024.108069. Epub 2024 Dec 22.

Authors

Affiliations

¹ University Hospital Zürich, Department of Neurology, Zürich, Switzerland.
² University Hospital Zürich, Department of Medical Oncology and Hematology, Zürich, Switzerland.
³ ETOP Statistical Office, Frontier-Science Foundation Hellas, Athens, Greece.
⁴ University Hospital Zürich, Department of Dermatology, Zürich, Switzerland.
⁵ University Hospital Zürich, Department of Radiation Oncology, Zürich, Switzerland.
⁶ Coordinating Center, ETOP IBCSG Partners Foundation, Bern, Switzerland.
⁷ University of Siena, Center for Immuno-Oncology, University Hospital of Siena, Italy.
⁸ Clinical Trial Unit: Phase 1 and Precision Medicine, IRCCS, National Cancer Institute, Regina Elena, Rome, Italy.
⁹ Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.
¹⁰ Netherlands Cancer Institute, Amsterdam, the Netherlands.
¹¹ Royal Marsden Hospital, London, UK.
¹² Department of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
¹³ Kantonsspital Winterthur, Switzerland.
¹⁴ Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy.
¹⁵ University of Perugia, Medical Oncology Unit, Santa Maria Misericordia Hospital, Perugia, Italy.
¹⁶ Policlinico Umberto 1, Rome, Italy.
¹⁷ Vall d'Hebron Hospital Campus and Institute of Oncology (VHIO), Barcelona, Spain.
¹⁸ ETOP Statistical Office, Frontier-Science Foundation Hellas, Athens, Greece; National and Kapodistrian University of Athens, Athens, Greece.
¹⁹ CHUV, Lausanne, Switzerland.

PMID: 39731865
DOI: 10.1016/j.lungcan.2024.108069

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Immunotherapy or targeted therapy with or without stereotactic radiosurgery for patients with brain metastases from melanoma or non-small cell lung cancer - The ETOP 19-21 USZ-STRIKE study

Affiliations

Immunotherapy or targeted therapy with or without stereotactic radiosurgery for patients with brain metastases from melanoma or non-small cell lung cancer - The ETOP 19-21 USZ-STRIKE study

Authors

Affiliations

Conflict of interest statement

Publication types

LinkOut - more resources

Full Text Sources