Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec 28;14(1):31221.
doi: 10.1038/s41598-024-82589-z.

Impact of gut colonization by antibiotic-resistant bacteria on the outcomes of autologous stem cell transplantation in multiple myeloma

Marcin Jasiński  1   2 , Jarosław Biliński  3   4 , Martyna Maciejewska  1 , Karolina Ostrowska  5 , Patrycja Rusicka-Krzewska  1 , Wojciech Konarski  6 , Edyta Podsiadły  5   7 , Emilian Snarski  8 , Grzegorz W Basak  1   9
Affiliations

Impact of gut colonization by antibiotic-resistant bacteria on the outcomes of autologous stem cell transplantation in multiple myeloma

Marcin Jasiński et al. Sci Rep. .

Abstract

Patients undergoing autologous stem cell transplantation (auto-SCT) face elevated risks of infections. Additionally, patients colonized in the gastrointestinal tract with antibiotic-resistant bacteria (ARB) are at higher risk of infection with ARB and other infections. Therefore, patients colonized with ARB before auto-SCT should present with an exceptionally high incidence of infections. According to current literature, ARB colonization is the surrogate marker for dysbiosis, which is known to be associated with a diagnosis of multiple myeloma (MM). Given that, this retrospective study aimed to assess the influence of ARB colonization on infection rates, hematopoiesis regeneration, mucositis, overall survival, and progression-free survival following auto-SCT in MM. Data from 138 MM patients undergoing 141 auto-SCT were analyzed, with 15% showing ARB colonization. Among colonized patients, ESBL-producing gram-negative rods predominated. Patients with gut ARB colonization had significantly higher infection rates than non-colonized individuals (52 vs. 26%, P = 0.02), particularly bloodstream infections (43% vs. 14%, P = 0.004). Colonized patients also tended to exhibit shorter survival rates although there was no statistical significance (1-year and 2-year OS; non-colonized vs. colonized; 97 and 92% vs. 90 and 86%; p = 0.054). Based on our results, gut colonization before auto-SCT negatively affects treatment outcomes.

Keywords: Antibiotic-resistant bacteria; Autologous hematopoietic stem cell transplantation; Fecal microbiota transplantation; Gut colonization; Infection rates.

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Gut-colonizing ARB pathogens in the period of 3 months before auto-SCT.
Fig. 2
Fig. 2
Number of patients with other than bacteriemia infections 3 months after autoSCT and their etiologies (non-colonized group).
Fig. 3
Fig. 3
Number of patients with other than bacteriemia infections 3 months after autoSCT and their etiologies (colonized group).
Fig. 4
Fig. 4
Number of patients with positive blood cultures 3 months after autoSCT and their etiologies (non-colonized group).
Fig. 5
Fig. 5
Number of patients with positive blood cultures 3 months after autoSCT and their etiologies (colonized group).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Antimicrobial Resistance, C. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet399 (10325), 629–655 (2022). - PMC - PubMed
    1. Piddock, L. J. V. Reflecting on the final report of the O’Neill review on antimicrobial resistance. Lancet Infect. Dis.16 (7), 767–768 (2016). - PubMed
    1. Bilinski, J. et al. Impact of Gut colonization by antibiotic-resistant Bacteria on the outcomes of allogeneic hematopoietic stem cell transplantation: a retrospective, single-center study. Biol. Blood Marrow Transpl.22 (6), 1087–1093 (2016). - PubMed
    1. Kim, S. B. et al. Incidence and risk factors for carbapenem- and multidrug-resistant Acinetobacter baumannii bacteremia in hematopoietic stem cell transplantation recipients. Scand. J. Infect. Dis.46 (2), 81–88 (2014). - PubMed
    1. Thursby, E. & Juge, N. Introduction to the human gut microbiota. Biochem. J.474 (11), 1823–1836 (2017). - PMC - PubMed

Substances

LinkOut - more resources