Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort study
- PMID: 39733192
- PMCID: PMC11682055
- DOI: 10.1038/s41598-024-83260-3
Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort study
Abstract
This study aimed to investigate the relationship between unintentional weight loss and 30-day mortality in sepsis patients in the intensive care unit (ICU). A retrospective cohort study sepsis patients in the ICU was conducted using data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, involving 1842 sepsis patients in the ICU. We utilized multivariate Cox regression analysis to evaluate the association between unintentional weight loss and the risk of 30-day mortality. In addition, we conducted stratified and interaction analyses to determine the consistency of this association across various demographic and clinical subgroups. Out of the 1842 patients, 19.2% (354) died within 30 days. The fully adjusted multivariate Cox regression model revealed that for every one-unit decrease in body weight, the risk of death increased by 58% (hazard ratio [HR] = 1.58; 95% confidence interval [CI] = 1.20-2.07). Unintentional weight loss was found to be positively correlated with 30-day mortality. Subgroup analysis yielded consistent results across all groups. Unintentional weight loss was positively associated with a greater risk of mortality in critically ill patients with sepsis in the ICU.
Keywords: 30-day mortality; Retrospective cohort study; Sepsis; Unintentional weight loss.
© 2024. The Author(s).
Conflict of interest statement
Declarations. Competing interests: The authors declare no competing interests.
Figures
Similar articles
-
A retrospective study utilized MIMIC-IV database to explore the potential association between triglyceride-glucose index and mortality in critically ill patients with sepsis.Sci Rep. 2024 Oct 15;14(1):24081. doi: 10.1038/s41598-024-75050-8. Sci Rep. 2024. PMID: 39402158 Free PMC article.
-
Effect of changes trajectory of serum phosphate levels on the 28-day mortality risk in patients with sepsis: a retrospective cohort study from the MIMIC-IV database.BMC Infect Dis. 2025 Feb 21;25(1):245. doi: 10.1186/s12879-025-10547-9. BMC Infect Dis. 2025. PMID: 39984839 Free PMC article.
-
Stress hyperglycemia ratio as a mortality predictor in non-diabetic septic patients: a retrospective cohort analysis.BMC Infect Dis. 2025 May 25;25(1):752. doi: 10.1186/s12879-025-11151-7. BMC Infect Dis. 2025. PMID: 40414847 Free PMC article.
-
Association between the anion-gap and 28-day mortality in critically ill adult patients with sepsis: A retrospective cohort study.Medicine (Baltimore). 2024 Jul 26;103(30):e39029. doi: 10.1097/MD.0000000000039029. Medicine (Baltimore). 2024. PMID: 39058855 Free PMC article.
-
Association Between Dexamethasone and Delirium in Critically Ill Patients: A Retrospective Cohort Study of a Large Clinical Database.J Surg Res. 2021 Jul;263:89-101. doi: 10.1016/j.jss.2021.01.027. Epub 2021 Feb 24. J Surg Res. 2021. PMID: 33639374
Cited by
-
Obesity as a Risk Factor in Pediatric Sepsis: A Retrospective Comparative Study Under the Phoenix Definition.J Clin Med. 2025 Feb 26;14(5):1568. doi: 10.3390/jcm14051568. J Clin Med. 2025. PMID: 40095526 Free PMC article.
References
-
- Weng, L. et al. Sepsis-related mortality in China: A descriptive analysis. Intensive Care Med.44(7), 1071–1080. 10.1007/s00134-018-5203-z (2018). - PubMed
-
- Reinhart, K. et al. Recognizing sepsis as a global health priority—A WHO resolution. N. Engl. J. Med.377(5), 414–417. 10.1056/NEJMp1707170 (2017). - PubMed
-
- Fleischmann, C. et al. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am. J. Respir. Crit. Care Med.193(3), 259–272. 10.1164/rccm.201504-0781OC (2016). - PubMed
MeSH terms
LinkOut - more resources
Full Text Sources
Medical