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. 2024 Dec 28;14(1):31535.
doi: 10.1038/s41598-024-83260-3.

Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort study

Weide Lin  1 , Bixia Lin  2 , Junfan Chen  1 , Renwei Li  1 , Yaohua Yu  1 , Shiqing Huang  1 , Shurong Li  1 , Jing Lin  1
Affiliations

Impact of unintentional weight loss on 30-day mortality in intensive care unit sepsis patients: a retrospective cohort study

Weide Lin et al. Sci Rep. .

Abstract

This study aimed to investigate the relationship between unintentional weight loss and 30-day mortality in sepsis patients in the intensive care unit (ICU). A retrospective cohort study sepsis patients in the ICU was conducted using data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, involving 1842 sepsis patients in the ICU. We utilized multivariate Cox regression analysis to evaluate the association between unintentional weight loss and the risk of 30-day mortality. In addition, we conducted stratified and interaction analyses to determine the consistency of this association across various demographic and clinical subgroups. Out of the 1842 patients, 19.2% (354) died within 30 days. The fully adjusted multivariate Cox regression model revealed that for every one-unit decrease in body weight, the risk of death increased by 58% (hazard ratio [HR] = 1.58; 95% confidence interval [CI] = 1.20-2.07). Unintentional weight loss was found to be positively correlated with 30-day mortality. Subgroup analysis yielded consistent results across all groups. Unintentional weight loss was positively associated with a greater risk of mortality in critically ill patients with sepsis in the ICU.

Keywords: 30-day mortality; Retrospective cohort study; Sepsis; Unintentional weight loss.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Schematic representation of the participant selection process and distribution of participant groups.
Fig. 2
Fig. 2
Kaplan–Meier analysis of Unintentional weight loss in patients with sepsis.
Fig. 3
Fig. 3
The forest plots of sub-group analysis.
See this image and copyright information in PMC

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