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Comment
. 2024 Dec 28;45(1):11.
doi: 10.1007/s00296-024-05766-3.

COVID-19 is a trigger of autoimmune rheumatic diseases: a hypothesis tested over time

Aisulu Karkabayeva  1 , Khilola Mirakhmedova  2 , Shoira Khusinova  3 , Abdimutalib Mamasaidov  4 , Chokan Baimukhamedov  5
Affiliations
Comment

COVID-19 is a trigger of autoimmune rheumatic diseases: a hypothesis tested over time

Aisulu Karkabayeva et al. Rheumatol Int. .

Abstract

We discuss the paper recently published in Rheumatology Internationa. This article reflects on the prevalence of autoimmune rheumatic diseases (ARD) during the COVID-19 pandemic (2020-2023) and compares the same with the pre-pandemic period (2016-2019). We assume that SARS-CoV-2 triggers ARD. This study concerns the 10 million population of Greece, and this work convincingly confirms our hypothesis. Besides, four large cohort studies have demonstrated an increased incidence of autoimmune diseases after surviving COVID-19. Compared to the prepandemic period, all ARD increased, and RA growth in the index study reached a level of more than 20% during the pandemic. A similar trend was observed in our report covering four Central Asian republics, namely Kazakhstan, Kyrgyzstan, Uzbekistan, and Tajikistan. The alarming growth of ARDs due to the consequences of the pandemic can still be predicted for the coming years. Healthcare professionals worldwide should be aware of this hypothesis to plan their COVID-19, long COVID, and ARD diagnostic and therapeutic strategies. We agree with the authors of the index article that more resources and research studies are warranted to optimize the diagnosis and treatment of ARDs in this challenging time.

Keywords: Arthritis; Autoimmune rheumatic diseases; COVID-19; Long COVID; Rheumatoid arthritis.

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Conflict of interest statement

Declarations. Conflict of interest: None declared.

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References

    1. Bournia VK, Fragoulis GE, Mitrou P, Tsolakidis A, Mathioudakis K, Vassilopoulos D, Tektonidou M, Paraskevis D, Sfikakis PP (2024) Increased prevalence of inflammatory arthritis, systemic lupus erythematosus and systemic sclerosis, during 2020–2023 versus 2016–2019 in a nation-wide Cohort Study. Rheumatol Int 44(12):2837–2846. https://doi.org/10.1007/s00296-024-05733-y - DOI - PubMed
    1. Syed U, Subramanian A, Wraith DC, Lord JM, McGee K, Ghokale K, Nirantharakumar K, Haroon S (2023) Incidence of immune-mediated inflammatory diseases following COVID-19: a matched cohort study in UK primary care. BMC Med 21(1):363. https://doi.org/10.1186/s12916-023-03049-5 - DOI - PubMed - PMC
    1. Lim SH, Ju HJ, Han JH, Lee JH, Lee WS, Bae JM et al (2023) Autoimmune and autoinflammatory connective tissue disorders following COVID-19. JAMA Netw Open 6(10):e2336120. https://doi.org/10.1001/jamanetworkopen.2023.36120 - DOI - PubMed - PMC
    1. Chang R, Yen-Ting Chen T, Wang SI, Hung YM, Chen HY, Wei CJ (2023) Risk of autoimmune diseases in patients with COVID-19: a retrospective cohort study. EClinicalMedicine 56:101783. https://doi.org/10.1016/j.eclinm.2022.101783 - DOI - PubMed - PMC
    1. Tesch F, Ehm F, Vivirito A, Wende D, Batram M, Loser F et al (2023) Incident autoimmune diseases in association with SARS-CoV-2 infection: a matched cohort study. Clin Rheumatol 42(10):2905–2914. https://doi.org/10.1007/s10067-023-06670-0 - DOI - PubMed - PMC

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