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Review
. 2025 Jan;39(1):91-96.
doi: 10.13201/j.issn.2096-7993.2025.01.019.

[Research progress of liposome drug delivery system in the treatment of head and neck cancer]

[Article in Chinese]
Bo Liu  1 , Yaqin Tu  1 , Nan Wu  1 , Hongjun Xiao  1
Affiliations
Review

[Research progress of liposome drug delivery system in the treatment of head and neck cancer]

[Article in Chinese]
Bo Liu et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2025 Jan.

Abstract
in English, Chinese

Head and neck tumors are one of the major diseases that threaten human health. Targeted chemotherapy is an important treatment for head and neck tumors. However, many anti-cancer drugs are difficult to reach effective concentrations in tumors and can cause damage to normal tissues. Therefore, the efficient delivery of anti-tumor drugs, improvement of their therapeutic effects, and reduction of their adverse effects on the whole body and locally are urgent issues in targeted drug research. Liposomes have been widely studied due to their unique characteristics, including amphiphilicity, biocompatibility, biodegradability, and low toxicity. This article outlines the current applications and prospects of liposome drug delivery systems in different treatment modalities for head and neck tumors in recent years, aiming to provide more options for the treatment of head and neck tumors.

摘要: 头颈肿瘤是危害人类健康的重大疾病之一，靶向化疗是针对头颈肿瘤的一项重要治疗手段。但是，许多抗癌药物难以在肿瘤中达到有效浓度，并会对正常组织造成损害。因此，如何高效递送抗肿瘤药物、提升其治疗效果并降低其对全身和局部的不良反应，是靶向药物研究中亟需解决的问题。脂质体因其独特的特性，包括两亲性，生物相容性，生物降解性，低毒性等，而受到了广泛研究。本文概述了近年来脂质体药物递送系统在头颈肿瘤不同治疗方式中的应用现状及前景，以期为头颈肿瘤的治疗提供更多可选方案。.

Keywords: cancer treatment; drug delivery systems; head and neck cancer; liposomes.

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Conflict of interest statement

The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.

Figures

图 1
图 1
各种功能脂质体示意图
图 2
图 2
脂质体在肿瘤组织中被动靶向和主动靶向示意图
See this image and copyright information in PMC

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