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. 2024 Dec 12:15:1500918.
doi: 10.3389/fneur.2024.1500918. eCollection 2024.

Short-term efficacy of right-to-left shunt closure in patients with vestibular migraine

Yilin Lang #  1 , Sai Zhang #  1 , Peifan Xie  1 , Yang Wang  1 , Chuangwei Wang  1 , Wenting Wang  1 , Xien Zhu  1 , Ping Gu  1
Affiliations

Short-term efficacy of right-to-left shunt closure in patients with vestibular migraine

Yilin Lang et al. Front Neurol. .

Abstract

Objective: This study aims to evaluate the short-term efficacy of right-to-left shunt closure in vestibular migraine patients, and compare the efficacy between patent foramen ovale (PFO) closure and pulmonary arteriovenous malformation (PAVM) embolization. Additionally, the study identifies factors related to surgical outcomes.

Methods: Forty-one patients with vestibular migraine and medium to large right-to-left shunts underwent surgery: PFO closure, PAVM embolization, or both. Baseline data and postoperative outcomes at one month, including migraine and dizziness frequency, duration, VAS, HIT-6, migraine scores, and DHI scores, were analyzed. The correlation between efficacy and baseline data was analyzed.

Results: At one month postoperatively, the frequency and duration of dizziness and migraine attacks significantly decreased, and the VAS, HIT-6, migraine scores, and DHI scores all significantly dropped (p < 0.001). There was no significant difference in the improvement rates of VAS, HIT-6, migraine scores, and DHI scores between the PFO group and the PAVM group (p > 0.05). Red blood cell parameters positively correlated with the improvement rates of VAS, HIT-6, migraine scores, and DHI. This approach was more effective in male patients than in female patients (p < 0.05).

Conclusion: Right-to-left shunt closure has a significant short-term effect on patients with vestibular migraine, regardless of the shunt location. Red blood cell parameters may serve as predictive indicators for the surgical efficacy in these patients.

Keywords: efficacy; patent foramen ovale; pulmonary arteriovenous malformation; right-to-left shunt closure; vestibular migraine.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Changes in frequency and duration of migraine and dizziness in VM patients. (Note: a. Frequency of migraine in VM patients; b. Frequency of dizziness in VM patients; c. Duration of migraine in VM patients; d. Duration of dizziness in VM patients. T1 - preoperative; T2 - 1 month postoperative).
Figure 2
Figure 2
Comparison of scores between the PFO group and the PAVM group postoperatively. (Note: T1 - preoperative; T2 - 1 month postoperative).
Figure 3
Figure 3
Factors related to surgical efficacy. (Note: *p < 0.05; IR: Improvement Rate).
See this image and copyright information in PMC

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