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Editorial
. 2024 Dec 26;16(12):677-682.
doi: 10.4330/wjc.v16.i12.677.

Catheter ablation using pulsed-field energy: Do we finally have the magic wand to defeat atrial fibrillation?

Ernesto Cristiano  1 , Hussam Ali  2 , Eduardo Celentano  1   3 , Riccardo Cappato  4
Affiliations
Editorial

Catheter ablation using pulsed-field energy: Do we finally have the magic wand to defeat atrial fibrillation?

Ernesto Cristiano et al. World J Cardiol. .

Abstract

Clinical outcomes of catheter ablation remain suboptimal in patients with atrial fibrillation (AF), particularly in those with persistent AF, despite decades of research, clinical trials, and technological advancements. Recently, pulsed-field ablation (PFA), a promising non-thermal technology, has been introduced to improve procedural outcomes. Its unique feature of myocardial selectivity offers safety advantages by avoiding potential harm to vulnerable adjacent structures during AF ablation. However, despite the global enthusiasm within the electrophysiology community, recent data indicate that PFA is still far from being a "magic wand" for addressing such a complex and challenging arrhythmia as AF. More progress is needed in mapping processes rather than in ablation technology. This editorial reviews relevant available data and explores future research directions for PFA.

Keywords: Atrial fibrillation; Cardiac arrhythmias; Catheter ablation; Electroanatomic mapping; Electroporation; Interventional cardiology; Pulsed field ablation; Radiofrequency ablation.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

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References

    1. Lippi G, Sanchis-Gomar F, Cervellin G. Global epidemiology of atrial fibrillation: An increasing epidemic and public health challenge. Int J Stroke. 2021;16:217–221. - PubMed
    1. Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, Boriani G, Castella M, Dan GA, Dilaveris PE, Fauchier L, Filippatos G, Kalman JM, La Meir M, Lane DA, Lebeau JP, Lettino M, Lip GYH, Pinto FJ, Thomas GN, Valgimigli M, Van Gelder IC, Van Putte BP, Watkins CL. Corrigendum to: 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42:4194. - PubMed
    1. Reddy VY, Dukkipati SR, Neuzil P, Anic A, Petru J, Funasako M, Cochet H, Minami K, Breskovic T, Sikiric I, Sediva L, Chovanec M, Koruth J, Jais P. Pulsed Field Ablation of Paroxysmal Atrial Fibrillation: 1-Year Outcomes of IMPULSE, PEFCAT, and PEFCAT II. JACC Clin Electrophysiol. 2021;7:614–627. - PubMed
    1. Gallagher JJ, Svenson RH, Kasell JH, German LD, Bardy GH, Broughton A, Critelli G. Catheter technique for closed-chest ablation of the atrioventricular conduction system. N Engl J Med. 1982;306:194–200. - PubMed
    1. Wittkampf FH, van Driel VJ, van Wessel H, Neven KG, Gründeman PF, Vink A, Loh P, Doevendans PA. Myocardial lesion depth with circular electroporation ablation. Circ Arrhythm Electrophysiol. 2012;5:581–586. - PubMed

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