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. 2024 Dec 24:17:6431-6442.
doi: 10.2147/IJGM.S493385. eCollection 2024.

Impact of Anemia and Acquired Anemia on in-Hospital Mortality of Acute Coronary Syndrome Patients

Idris Yakut  1 , Emir Dervis  1
Affiliations

Impact of Anemia and Acquired Anemia on in-Hospital Mortality of Acute Coronary Syndrome Patients

Idris Yakut et al. Int J Gen Med. .

Abstract

Objective: To investigate the associations of anemia-related parameters, with in-hospital mortality after acute coronary syndrome (ACS), as well as factors associated with prior anemia (PA) and hospital-acquired anemia (HAA) in patients with ACS.

Methods: This was a retrospective cohort study conducted between June 2021 and May 2023. The data of patients diagnosed with ACS who were hospitalized and treated in our hospital were recorded, including age and sex, smoking and comorbidity status, laboratory findings, CHA2DS2-VASc scores, prior medication use, left ventricular ejection fraction, ACS type, the synergy between percutaneous intervention with taxus drug-eluting stents and cardiac surgery (SYNTAX) scores, stent thrombosis status and mortality status. Mortality was assessed according to in-hospital death. Patients were grouped based on anemia presence (PA and HAA).

Results: A total of 329 patients were included in the study. Of these, 219 (66.56%) were in the no anemia group, 58 (17.63%) in the PA group, and 52 (15.81%) in the HAA group. The mean age of all participants was 61.27±12.45 years and 76.29% of them were male. 14 (4.26%) patients died during hospitalization. Multivariable logistic regression analysis had revealed that, prior coronary artery disease (OR: 3.779, 95% CI: 1.141-12.508, p=0.030), PA (OR: 7.043, 95% CI: 1.574-31.517, p = 0.011), HAA (OR: 5.857, 95% CI: 1.260-27.236, p=0.024) and high WBC (OR: 1.190, 95% CI: 1.028-1.378, p=0.020) were independently associated with the increased risk of in-hospital mortality.

Conclusion: Consequently, the risk of in-hospital mortality is higher in patients with a previous history of coronary artery disease, PA, HAA and high WBC, and additional precautions should be taken in these patients.

Keywords: acute coronary syndrome; anemia; mortality.

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Conflict of interest statement

The authors have no conflicts of interest to declare in this work.

Figures

Figure 1
Figure 1
Flowchart of the study.
Figure 2
Figure 2
In-hospital mortality according to the anemia status.
See this image and copyright information in PMC

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References

    1. Babes EE, Zaha DC, Tit DM, et al. Value of hematological and coagulation parameters as prognostic factors in acute coronary syndromes. Diagnostics. 2021;11(5):850. doi:10.3390/diagnostics11050850 - DOI - PMC - PubMed
    1. Yeh RW, Sidney S, Chandra M, Sorel M, Selby JV, Go AS. Population trends in the incidence and outcomes of acute myocardial infarction. N Engl J Med. 2010;362(23):2155–2165. doi:10.1056/NEJMoa0908610 - DOI - PubMed
    1. Nutritional anaemias. Report of a WHO scientific group. World Health Organ Tech Rep Ser. 1968;405:5–37. - PubMed
    1. Stucchi M, Cantoni S, Piccinelli E, Savonitto S, Morici N. Anemia and acute coronary syndrome: current perspectives. Vasc Health Risk Manag. 2018;14:109–118. doi:10.2147/vhrm.S140951 - DOI - PMC - PubMed
    1. Meneveau N, Schiele F, Seronde MF, et al. Anemia for risk assessment of patients with acute coronary syndromes. Am J Cardiol. 2009;103(4):442–447. doi:10.1016/j.amjcard.2008.10.023 - DOI - PubMed

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