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. 2024 Jul;19(3):140-143.
doi: 10.1016/j.joto.2024.04.003. Epub 2024 Oct 23.

Preliminary study of the role of inner ear proteins in vestibular neuritis

Rong Wang  1   2 , Weiwei Han  3 , Li Li  1 , Lulu Li  1 , Xiaoxia Liu  1 , Yunqin Wu  1 , Weinv Fan  1
Affiliations

Preliminary study of the role of inner ear proteins in vestibular neuritis

Rong Wang et al. J Otol. 2024 Jul.

Abstract

Objective: To evaluate the plasma levels of the otoconial proteins, otoconin-90 and otolin-1, in individuals diagnosed with vestibular neuritis (VN) and determine the feasibility of using these proteins as biomarkers for VN.

Methods: In this preliminary study, 30 patients diagnosed with VN and 70 healthy individuals were recruited and followed to confirm whether they had benign paroxysmal positional vertigo (BPPV) during the following time. The recorded data included measurements of height, weight, and history of diabetes mellitus or hypertension. Additionally, levels of plasma otoconin-90, and otolin-1 were measured and compared.

Results: The plasma concentrations of otoconin-90 and otolin-1 may not be significantly different between patients with VN and healthy controls, nor among patients with BPPV secondary to VN and patients with VN without BPPV.

Conclusions: Plasma otoconin-90 and otolin-1 levels may not serve as biomarkers of acute VN episodes or predict BPPV occurrence secondary to VN.

Keywords: Inner ear protein; Otoconin-90; Otolin-1; Vestibular neuritis.

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Conflict of interest statement

All authors have no potential conflicts of interest to be disclosed.

Figures

Fig. 1
Fig. 1
Plasma otoconin-90 concentration in patients with VN and controls.
Fig. 2
Fig. 2
Plasma otolin-1 concentration in patients with VN and controls.
See this image and copyright information in PMC

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