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. 2024 Dec 16:14:1474998.
doi: 10.3389/fcimb.2024.1474998. eCollection 2024.

Diagnostic and prognostic values of NSCLC patients with or without obstructive pneumonia after sleeve lobectomy

Yuxia Huang #  1   2 , Lan Zhang #  3 , Wentian Zhang  2 , Na Lv #  3 , Tao Wang #  2
Affiliations

Diagnostic and prognostic values of NSCLC patients with or without obstructive pneumonia after sleeve lobectomy

Yuxia Huang et al. Front Cell Infect Microbiol. .

Abstract

Objective: We aimed to identify the diagnostic value of next-generation sequencing (NGS) of bronchoalveolar lavage fluid (BALF) from patients with non-small-cell lung cancer (NSCLC).

Methods: Forty patients who were initially diagnosed with pulmonary nodules were enrolled. Frozen section histology was used to identify the NSCLC cell types. NGS of collected BALF samples was used for microbial identification. We compared the bacterial and viral distributions in BALF samples from patients with NSCLC with and without obstructive pneumonia as well as their NSCLC drainage times following surgery.

Results: Of the 29 patients with NSCLC, eight had obstructive pneumonia. Streptococcus pneumoniae, Streptococcus pseudopneumoniae, and Haemophilus parainfluenzae were the top three bacteria present in almost 50% of patients, both with and without obstructive pneumonia. The viral detection rate was higher in the BALF of patients with NSCLC who did not have obstructive pneumonia. However, in patients with NSCLC and drain times of >5 days, the human herpes virus type 7 detection rate was higher following surgery than it was in patients with NSCLC who had drain times of ≤5 days.

Conclusion: Viral imbalance in NSCLC is closely related to the occurrence of obstructive pneumonia and postoperative drainage time.

Keywords: bronchoalveolar lavage fluid; lung resection; next-generation sequencing; non-small-cell lung cancer; obstructive pneumonia.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Bacterial distribution characteristics in NSCLC with or without obstructive pneumonia. Obstructive pneumonia has an impact on the microbial population of NSCLC.
Figure 2
Figure 2
Distribution characteristics of pathogenic microorganisms in NSCLC patients with or without obstructive pneumonia.
See this image and copyright information in PMC

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