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Editorial
. 2024 Dec 28;30(48):5104-5110.
doi: 10.3748/wjg.v30.i48.5104.

Bidirectional relationship between gastrointestinal cancer and depression: The key is in the microbiota-gut-brain axis

Bryan Adrian Priego-Parra  1 , Jose Maria Remes-Troche  2
Affiliations
Editorial

Bidirectional relationship between gastrointestinal cancer and depression: The key is in the microbiota-gut-brain axis

Bryan Adrian Priego-Parra et al. World J Gastroenterol. .

Abstract

In this Editorial, we review the recent publication in the World Journal of Gastroenterology, which explores the complex relationship between depression and gastric cancer and offers perspectives. Key topics discussed include the microbiota-gut-brain axis, dysbiosis, and the influence of microbial metabolites in homeostasis. Additionally, we address toxic stress caused by hypothalamic-pituitary-adrenal axis dysregulation, psychological assessments, and future research directions. Our Editorial aims to expand the understanding of the bidirectional relationship between depression and gastrointestinal cancer.

Keywords: Depression; Dysbiosis; Gastric cancer; Microbiota-gut-brain axis; Mood disorders; Psychogastroenterology.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare no conflicts of interest related to this work.

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