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Review
. 2024 Dec 13:15:1492610.
doi: 10.3389/fendo.2024.1492610. eCollection 2024.

Mechanism and application prospect of ferroptosis inhibitors in improving osteoporosis

Jing Wang #  1 , TingRui Chen #  1 , Fei Gao  1
Affiliations
Review

Mechanism and application prospect of ferroptosis inhibitors in improving osteoporosis

Jing Wang et al. Front Endocrinol (Lausanne). .

Abstract

Osteoporosis, a prevalent bone metabolic disorder, has emerged as a pressing global public health concern. Recent studies have illuminated a crucial link between ferroptosis and the pathogenesis of osteoporosis. Nevertheless, the intricate mechanisms underlying the role of ferroptosis in this condition remain largely unexplored. Therefore, this article comprehensively reviews the regulatory mechanisms of ferroptosis and the modulating effects on the development and progression of osteoporosis, as reported in recent years. Furthermore, this review summarizes the current state of the interventional strategies employed by both Western medicines and traditional Chinese medicines (TCMs) in addressing osteoporosis. This review aims to uncover potential novel avenues for the prevention and control of osteoporosis by synthesizing the modes of action and clinical efficacy of these therapeutic modalities.

Keywords: Western medicines; ferroptosis; iron overload; lipid peroxidation; osteoporosis; traditional Chinese medicines.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Mechanism and regulation of ferroptosis.
See this image and copyright information in PMC

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