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. 2024 Dec 13:11:1478090.
doi: 10.3389/fmed.2024.1478090. eCollection 2024.

Relationship between triglyceride glucose-body mass index and coronary artery calcium score in maintenance hemodialysis patients

Zexi Jiang #  1 , Jinhua Zhu #  2 , Hong Ding  2 , Lihong Yan  1 , Ruoxin Chen  1 , Bin Wang  1 , ZuoLin Li  1 , Hong Liu  1
Affiliations

Relationship between triglyceride glucose-body mass index and coronary artery calcium score in maintenance hemodialysis patients

Zexi Jiang et al. Front Med (Lausanne). .

Abstract

Background: This study investigated the association between coronary artery calcification (CAC) and triglyceride glucose-body mass index (TyG-BMI) in patients receiving maintenance hemodialysis (MHD).

Methods: We used computed tomography (CT) to assess coronary artery calcification score (CACS) using the Agatston method. The TyG index was multiplied by BMI to derive the TyG-BMI index. Ordinal logistic regression models were used to analyze the relationship between TyG-BMI and CAC. The dose-response relationship was evaluated using restricted cubic spline regression. Weighted Quantile Sum regression was used to explore the weight of the TyG-BMI index components.

Results: Based on the TyG-BMI, 219 patients with MHD were stratified into three groups. The TyG-BMI index was shown to be an independent risk factor for CACS by multivariate ordinal logistic regression analysis (odds ratio, 1.011; [95% confidence interval, 1.002-1.021]; P = 0.021). The relationship between TyG-BMI and lg (CACS + 10) was linear (P-overall = 0.023, P-non-linear = 0.412). Body mass index (BMI) had the highest weight (0.566) when weights were assigned to the three components of TyG-BMI. In the non-diabetes and diabetes subgroups, TyG-BMI and lg (CACS + 10) did not exhibit a significant non-linear relationship.

Conclusion: TyG-BMI and CAC were independently positively correlated in patients undergoing MHD. These findings suggest that assessing TyG-BMI as a valuable tool for identifying the risk of CAC in patients with MHD.

Keywords: cardiovascular disease; coronary artery calcification; insulin resistance; maintenance hemodialysis; triglyceride glucose-body mass index.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Enrollment flowchart for this study. HD, hemodialysis.
FIGURE 2
FIGURE 2
Dose-response relationship between TyG-BMI index and lg (CACS + 10) in overall patients. Adjusted for age; sex; tobacco use; alcohol consumption; diabetes; hypertension; duration of dialysis; diastolic blood pressure; pulse pressure; fasting blood glucose; high-density lipoprotein cholesterol; hemoglobin; albumin and C-reactive protein. Odds ratios are indicated by solid lines and 95% CIs by shaded areas.
FIGURE 3
FIGURE 3
Estimated weights assigned to TyG-BMI with the WQS model. WQS models were adjusted for age; sex; tobacco use; alcohol consumption; diabetes; hypertension; duration of dialysis; diastolic blood pressure; pulse pressure; high-density lipoprotein cholesterol; hemoglobin; albumin and C-reactive protein. BMI, body mass index; FBG, fasting blood glucose; TG, triglyceride; WQS, weighted quantile sum.
FIGURE 4
FIGURE 4
Dose-response relationship between TyG-BMI index and lg (CACS + 10) in non-diabetes (A) and diabetes (B) patients. Adjusted for age; sex; tobacco use; alcohol consumption; hypertension; duration of dialysis; diastolic blood pressure; pulse pressure; fasting blood glucose; high-density lipoprotein cholesterol; hemoglobin; albumin and C-reactive protein. Odds ratios are indicated by solid lines and 95% CIs by shaded areas.
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