Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec 26;13(1):e70021.
doi: 10.1002/ccr3.70021. eCollection 2025 Jan.

Post-Artesunate Delayed Hemolysis: Anything That Can Go Wrong Will Go Wrong-Murphy's Law

Beliza Chemutai  1 , Muhammed Omar Ali  1 , Jaimin Vinod Varsani  2 , Derrick Bary Abila  2 , Denis Can Odonga  1 , Paska Apiyo  1 , Felix Bongomin  1   3
Affiliations

Post-Artesunate Delayed Hemolysis: Anything That Can Go Wrong Will Go Wrong-Murphy's Law

Beliza Chemutai et al. Clin Case Rep. .

Abstract

In patients presenting with post-malarial anemia following intravenous artesunate treatment, post-artesunate delayed hemolysis should be considered in the differential diagnosis, even in endemic settings. Close monitoring for signs of delayed hemolysis in patients previously treated with intravenous artesunate for severe malaria, regardless of their malaria exposure history or geographic location is crucial.

Keywords: Uganda; artesunate; malaria; plasmodium; post‐artesunate delayed hemolysis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Moxon C. A., Gibbins M. P., McGuinness D., Milner D. A., and Marti M., “New Insights Into Malaria Pathogenesis,” Annual Review of Pathology 15 (2020): 315–343, 10.1146/annurev-pathmechdis-012419-032640. - DOI - PubMed
    1. Cowman A. F., Healer J., Marapana D., and Marsh K., “Malaria: Biology and Disease,” Cell 167, no. 3 (2016): 610–624, 10.1016/j.cell.2016.07.055. - DOI - PubMed
    1. Kotepui M., Kotepui K. U., Milanez G. D., and Masangkay F. R., “Severity and Mortality of Severe Plasmodium Ovale Infection: A Systematic Review and Meta‐Analysis,” PLoS One 15, no. 6 (2020): e0235014, 10.1371/journal.pone.0235014. - DOI - PMC - PubMed
    1. Rahimi B. A., Thakkinstian A., White N. J., Sirivichayakul C., Dondorp A. M., and Chokejindachai W., “Severe Vivax Malaria: A Systematic Review and Meta‐Analysis of Clinical Studies Since 1900,” Malaria Journal 13, no. 1 (2014): 481, 10.1186/1475-2875-13-481. - DOI - PMC - PubMed
    1. Rajahram G. S., Barber B. E., William T., Menon J., Anstey N. M., and Yeo T. W., “Deaths due to Plasmodium Knowlesi Malaria in Sabah, Malaysia: Association With Reporting as Plasmodium Malariae and Delayed Parenteral Artesunate,” Malaria Journal 11, no. 1 (2012): 284, 10.1186/1475-2875-11-284. - DOI - PMC - PubMed

LinkOut - more resources