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Review
. 2024 Dec 24;29(12):426.
doi: 10.31083/j.fbl2912426.

The Display between HPV Infection and Host Immunity in Cervical Cancer

Yuanyuan Gu  1   2 , Tingting Li  3 , Menglei Zhang  1   2 , Junhao Chen  1   2 , Fang Shen  1   2 , Jingxin Ding  1   2 , Guannan Zhou  1   2 , Keqin Hua  1   2
Affiliations
Free article
Review

The Display between HPV Infection and Host Immunity in Cervical Cancer

Yuanyuan Gu et al. Front Biosci (Landmark Ed). .
Free article

Abstract

Most cervical cancers are related to the persistent infections of high-risk Human Papillomavirus (HPV) infections. Increasing evidence has witnessed the immunosuppressive effectiveness of HPV in the oncogenesis steps and progression steps. Here we review the immune response in HPV-related cervical malignancies and discuss the crosstalk between HPVs and the host immune response. Furthermore, we describe the identification and development of current immunotherapies in cervical cancer. Above all, we hope to provide a novel insight of the display between HPV infections and the host immune system.

Keywords: Human Papillomavirus (HPVs); cervical cancer; immune response; immunotherapies; landscape.

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