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Meta-Analysis
. 2024 Dec 30;24(1):756.
doi: 10.1186/s12872-024-04421-w.

Androgen deprivation therapy use and the risk of heart failure in patients with prostate cancer: a systematic review and meta-analysis

Amir Alinejad Khorram #  1 , Reyhaneh Pourasgharian #  2 , Ali Samadi Shams #  3 , Shahin Toufani  4 , Mehrsa Mostafaei  2 , Reza Khademi  5 , Reza Daghayeghi  6 , Maryam Valifard  7 , Mehregan Shahrokhi  8 , Sina Seyedipour  9 , Niloofar Deravi  10   11 , Mahdyieh Naziri  12 , Mahta Malek  13 , Faizan Bashir  8
Affiliations
Meta-Analysis

Androgen deprivation therapy use and the risk of heart failure in patients with prostate cancer: a systematic review and meta-analysis

Amir Alinejad Khorram et al. BMC Cardiovasc Disord. .

Abstract

Background & aim: We aimed in this study to investigate the relationship between Androgen Deprivation Therapy (ADT) use and the risk of heart failure in patients with prostate cancer. In this research, the negative or positive effects of ADT in the development of cardiovascular diseases or its exacerbation in people with prostate cancer have been investigated.

Materials and methods: For this research, we reviewed articles from PubMed, Scopus, and Google Scholar databases until February 2024. We extracted and screened titles, abstracts, and full texts of related articles. The quality of studies was assessed and extracted and analyzed data.

Result: A total of 9 studies comprising 189,045 patients were included in the meta-analysis, examining the association between androgen deprivation therapy (ADT) and heart failure. The overall pooled hazard ratio (HR) was 1.299 (95% CI: 1.003-1.595), indicating a significantly increased risk of heart failure with ADT. Subgroup analyses revealed that the risk was stronger in Asian populations (pooled HR = 1.545, 95% CI: 1.180-1.910) compared to North American populations (pooled HR = 0.779, 95% CI: 0.421-1.138).

Conclusions: ADT has a significant relationship with cardiovascular disease. According to the analysis, ADT has increased the risk of heart failure in people with prostate cancer by 30%.

Keywords: Androgen deprivation therapy; Cardiovascular disease; Prostate cancer; heart failure.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flow chart
Fig. 2
Fig. 2
Association of ADT and the risk of heart failure in patients with prostate cancer(total population)
Fig. 3
Fig. 3
Association of ADT and the risk of heart failure in patients with prostate cancer (A: North-America; B:Asia)
Fig. 4
Fig. 4
Association of ADT type and the risk of heart failure in patients with prostate cancer (A: GNRI agonists; B: GNRH antagonists or GNRH agonists)
See this image and copyright information in PMC

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