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Observational Study
. 2024 Dec 30;24(1):673.
doi: 10.1186/s12905-024-03535-9.

The relationship between serum progesterone level on the day of HCG trigger in IVF/ICSI cycles and oocyte maturation and embryo quality: a retrospective observational study

Elham Hokmabadi  1 , Elnaz Salahi  1 , Marzieh Ghasemi  2   3
Affiliations
Observational Study

The relationship between serum progesterone level on the day of HCG trigger in IVF/ICSI cycles and oocyte maturation and embryo quality: a retrospective observational study

Elham Hokmabadi et al. BMC Womens Health. .

Abstract

Purpose: Previous studies have suggested a link between serum progesterone levels on the day of the HCG trigger in IVF cycles and oocyte and embryo quality. This study aims to explore this relationship more thoroughly.

Methods: This study included 496 infertility patients at Moloud Infertility Treatment Center, Zahedan, Iran. Statistical methods were used to assess factors such as oocyte maturation and embryo quality, fertilization rate, BMI, and gonadotropin dosage.

Results: While an initial progesterone cutoff of 1.2 ng/ml was used to perform fundamental analysis, a more accurate cutoff of 1.54 ng/ml was identified, beyond which the average number of M1 oocytes significantly declined. A strong relationship was found between higher progesterone levels and a greater number of retrieved oocytes (p = 0.004), with M1 oocytes showing a similar relation. Also, BMI was significantly related to the quality of eight-cell grade B embryos (p = 0.006). However, no significant correlations were found between progesterone levels and other factors, including patient age (p = 0.327), fertilization rate (p = 0.603), or embryo quality at other stages.

Conclusions: The findings demonstrate that elevated progesterone level, particularly beyond the identified cutoff of 1.54 ng/ml, is a valuable clinical indicator of suboptimal IVF outcomes due to its negative impact on oocyte maturation.

Keywords: Embryo quality; HCG trigger; IVF; Infertility; Oocyte maturation; Progesterone.

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Conflict of interest statement

Declarations. Ethical approval: The studies involving human participants were reviewed and approved by the Zahedan University of Medical Sciences Ethics Committee and were conducted according to the guidelines on human experimentation of the 1975 Declaration of Helsinki. The patients/participants provided their written informed consent to participate in this study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Relationship between the average number of M1 oocytes and serum progesterone levels
Fig. 2
Fig. 2
ROC Curve for Predicting Oocyte Maturity Based on Progesterone Levels
See this image and copyright information in PMC

References

    1. Allen C, McLernon D, Bhattacharya S, Maheshwari A. Early pregnancy outcomes of IVF cycles using donor versus partner sperm: analysis of 1,376,454 cycles recorded by the Human Fertilisation and Embryology Authority (1991–2016). Hum Reprod. 2023;38(6):1194–201. - PubMed
    1. Ni Y, Shen H, Yao H, Zhang E, Tong C, Qian W, et al. Differences in fertility-related quality of life and emotional status among women undergoing different IVF treatment cycles. Psychol Res Behav Manag. 2023;16:1873–82. - PMC - PubMed
    1. Chiware TM, Vermeulen N, Blondeel K, Farquharson R, Kiarie J, Lundin K, et al. IVF and other ART in low-and middle-income countries: a systematic landscape analysis. Hum Reprod Update. 2021;27(2):213–28. - PMC - PubMed
    1. Ombelet W. Global access to infertility care in developing countries: a case of human rights, equity, and social justice. Facts Views Vis Obgyn. 2011;3(4):257–66. - PMC - PubMed
    1. Mahran A, Khairy M, Elkhateeb R, Hegazy AR, Abdelmeged A, Batiha GE, et al. The value of serum progesterone level on the day of human chorionic gonadotropin administration/metaphase II oocyte ratio in predicting IVF/ICSI outcome in patients with normal ovarian reserve. J Ovarian Res. 2021;14(1):52. - PMC - PubMed

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