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Review
. 2024 Dec 16:15:1462174.
doi: 10.3389/fimmu.2024.1462174. eCollection 2024.

AKR1B10 and digestive tumors development: a review

Yao Shen  1 , Ailin Qiu  2 , Xin Huang  3   4 , Xiaosha Wen  3 , Sundar Shehzadi  3 , Yan He  2 , Qian Hu  2 , Jian Zhang  1 , Dixian Luo  3 , Shenghui Yang  1   5
Affiliations
Review

AKR1B10 and digestive tumors development: a review

Yao Shen et al. Front Immunol. .

Abstract

Aldo-keto reductase family 1 member B10 (AKR1B10) is a member of the AKR1B subfamily. It is mainly found in cytoplasm, and it is typically expressed in the stomach and intestines. Given that its expression is low or absent in other tissues, AKR1B10 is a potential diagnostic and therapeutic biomarker for various digestive system diseases. Here, we review recent research progress on AKR1B10 in digestive system tumors such as hepatocellular carcinoma, gastric carcinoma, colorectal carcinoma, pancreatic carcinoma, oral squamous cell carcinoma, laryngeal squamous cell carcinoma, cholangiocarcinoma, and nasopharyngeal carcinoma, over the last 5 years. We also discuss the current trends and future research directions for AKR1B10 in both oncological and non-oncological diseases to provide a scientific reference for further exploration of this gene.

Keywords: AKR1B10; digestive system tumors; mechanisms; metabolism; review.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
AKR1B10 sequence and PTM sites. The amino acid sequence of AKR1B10 was obtained from the UniProt database (https://www.uniprot.org/), and the PTM sites were obtained from the PhosphoSitePlus database(https://www.phosphosite.org/) and PTMcode 2 database(PTMcode 2: Home (embl.de)).
Figure 2
Figure 2
AKR1B10 expression in digestive tract tumors. ↑: Upregulation of AKR1B10 expression; ↓: Downregulation of AKR1B10 expression.
Figure 3
Figure 3
Mechanism of AKR1B10 in digestive system tumors. AKR1B10 can play a role in digestive system tumors by participating in lipid synthesis, oxidative stress, and epithelial mesenchymal transition. An upward arrow indicates an increase in content and a downward arrow indicates a decrease in content.
Figure 4
Figure 4
Selected signaling pathways regulated by AKR1B10. AKR1B10 promotes IL-1α and IL-6 production in colon cancer cells by activating the NF-KB signaling pathway. Silencing the expression of AKR1B10 can regulate the Kras-E-cadherin pathway and inhibit the proliferation, invasion and metastasis of pancreatic cancer cells, and reduce the phosphorylation level of PI3K and AKT to promote the proliferation, migration and invasion of HCC cells.
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