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. 2024 Dec 25:17:4521-4531.
doi: 10.2147/JPR.S497061. eCollection 2024.

Efficacy and Safety of Ultrasound-Guided Pulsed Radiofrequency Therapy of Stellate Ganglion on Refractory Painful Diabetic Peripheral Neuropathy

Jiying Wang #  1 , Weisheng Xu #  1 , Qingqing Wang #  2 , Peng Yang #  3 , Yanpeng Kan  1 , Chao Huang  4 , Fuqing Lin  1
Affiliations

Efficacy and Safety of Ultrasound-Guided Pulsed Radiofrequency Therapy of Stellate Ganglion on Refractory Painful Diabetic Peripheral Neuropathy

Jiying Wang et al. J Pain Res. .

Abstract

Background: The best tool for the management of pain associated with distal symmetric peripheral neuropathy (DSPN) is a matter of debate. Therefore, the study aimed to explore whether ultrasound-guided pulsed radiofrequency (PRF) therapy of the stellate ganglion (SG) in type 2 diabetes mellitus (T2DM) patients with painful DSPN could decrease pain severity and the need for analgesics.

Methods: Fifty-six T2DM patients with refractory painful DSPN were enrolled in this study, who then received bilateral ultrasound-guided PRF therapy of SG. The patients completed visual analog scale (VAS), simplified McGill pain questionnaire (SF-MPQ), Toronto clinical score system (TCSS), sleep duration at night (SDN), pain disability index (PDI), Karnofsky performance status (KPS), and depression screening scale (PHQ-9). After procedures, the degree of perceived pain relief, numbness relief and chills relief of the patients, and side effects were assessed. All patients underwent evaluation after the last procedure at 1, 4, 12 and 24-week follow-up periods.

Results: The postoperative VAS, SF-MPQ, TCSS, PDI and PHQ-9 scores were significantly lower, while the KPS values higher than the preoperative (P<0.05). The postoperative SDN was longer than the preoperative (P<0.05). The degree of perceived pain relief, chills relief, and numbness relief at 4, 12, and 24 weeks were lower than that at 1 week after the procedures (P<0.05). The postoperative rates of administration of analgesic were lower than those of preoperative period (P<0.05). The significant effective rates at 1, 4, 12, and 24 weeks after the procedure were 67.86%, 42.86%, 21.43%, and 17.86% and the total effective rates were 89.29%, 71.43%, 46.43%, and 32.14%. No serious complication was observed.

Conclusion: Ultrasound-guided stellate ganglion PRF therapy can effectively relieve pain and improve the quality of life in T2DM patients with refractory painful DSPN.

Keywords: painful diabetic neuropathy; pulsed radiofrequency; stellate ganglion; type 2 diabetes mellitus.

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Conflict of interest statement

The authors have declared that no conflict of interest exists. This paper has been uploaded to Research Square as a preprint: https://doi.org/10.21203/rs.3.rs-3128530/v1.

Figures

Figure 1
Figure 1
Disposition of all patients screened for study participation.
Figure 2
Figure 2
Treatment position of ultrasound-guided pulsed radiofrequency therapy of stellate ganglion.
Figure 3
Figure 3
Ultrasound guided image of SG. The structure of continuously strongly echoing lumpiness on the surface of the longus cervicalis muscle between C7 to T1 levels (A). Ultrasound image of needle tip insertion site was placed in the structure of continuously strongly echoing lumpiness, on the surface of longus colli muscle, under the prevertebral fascia. White arrow indicates where needle is located (B).
See this image and copyright information in PMC

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References

    1. Watson JC, Dyck PJB. Peripheral neuropathy: a practical approach to diagnosis and symptom management. Mayo Clin Proc. 2015;90(7):940–951. doi:10.1016/j.mayocp.2015.05.004 - DOI - PubMed
    1. Shabeeb D, Najafi M, Hasanzadeh G, Hadian MR, Musa AE, Shirazi A. Electrophysiological measurements of diabetic peripheral neuropathy: a systematic review. Diab Metab Syndr. 2018;12(4):591–600. doi:10.1016/j.dsx.2018.03.026 - DOI - PubMed
    1. Ardeleanu V, Toma A, Pafili K, et al. Current pharmacological treatment of painful diabetic neuropathy: a narrative review. Medicina. 2020;56(1). doi:10.3390/medicina56010025 - DOI - PMC - PubMed
    1. Schmader KE. Epidemiology and impact on quality of life of postherpetic neuralgia and painful diabetic neuropathy. Clin J Pain. 2002;18(6):350–354. doi:10.1097/00002508-200211000-00002 - DOI - PubMed
    1. Kim MK, Yi MS, Park PG, Kang H, Lee JS, Shin HY. Effect of stellate ganglion block on the regional hemodynamics of the upper extremity: a randomized controlled trial. Anesth Analg. 2018;126(5):1705–1711. doi:10.1213/ANE.0000000000002528 - DOI - PubMed

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