Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025 Jan;24(1):e16750.
doi: 10.1111/jocd.16750.

Leveraging Single Nucleotide Polymorphism Profiling for Precision Skin Care: How SNPs Shape Individual Responses in Cosmetic Dermatology

Diala Haykal  1
Affiliations
Review

Leveraging Single Nucleotide Polymorphism Profiling for Precision Skin Care: How SNPs Shape Individual Responses in Cosmetic Dermatology

Diala Haykal. J Cosmet Dermatol. 2025 Jan.

Abstract

Introduction: Single-nucleotide polymorphisms (SNPs) represent a significant genetic variation influencing individual responses to cosmetic dermatology treatments. SNP profiling offers a pathway to personalized skincare by enabling practitioners to predict patient outcomes, customize interventions, and mitigate risks.

Background: The integration of genetic insights into dermatology has gained traction, with SNP analysis revealing predispositions in skin characteristics, such as collagen degradation, pigmentation, and inflammatory responses. Key SNPs, including MMP1, SOD2, TYR, and IL-6, are pivotal in determining skin health and treatment outcomes. Despite its promise, the adoption of SNP profiling in cosmetic dermatology is in its infancy, requiring further exploration of its practical applications.

Results: SNPs significantly influence skin responses to aesthetic treatments, offering insights for personalized care. Variations in MMP1 correlate with collagen degradation, suggesting collagen-stimulating therapies, while SOD2 SNPs highlight the need for antioxidant support. TYR variations affect pigmentation risks in light-based treatments, and IL-6 SNPs reveal inflammatory predispositions, guiding anti-inflammatory protocols. AI integration enhances SNP profiling by improving prediction accuracy and treatment customization. Challenges remain, including standardization, ethical considerations, and cost-effectiveness. Combining genetic insights with epigenetics and leveraging AI technologies can amplify precision and safety in dermatologic care.

Conclusion: SNP profiling marks a transformative step toward precision medicine in cosmetic dermatology, enabling tailored treatments that enhance efficacy and minimize adverse effects. Integrating AI-driven SNP analysis with epigenetic insights provides a comprehensive approach to patient care, fostering a new era of personalized skincare that respects genetic and environmental interactions. This paradigm shift holds the potential to redefine dermatologic practices, improving outcomes and patient satisfaction.

Keywords: cosmetic dermatology; genetic predisposition; personalized skincare; precision medicine; single nucleotide polymorphisms (SNPs) profiling.

PubMed Disclaimer

Conflict of interest statement

The author declares no conflicts of interest.

Similar articles

See all similar articles

References

    1. Kim I. Y., Kim J. H., Choi J. E., et al., “The First Broad Replication Study of SNPs and a Pilot Genome‐Wide Association Study for Androgenetic Alopecia in Asian Populations,” Journal of Cosmetic Dermatology 21, no. 11 (2022): 6174–6183, 10.1111/jocd.15187. - DOI - PubMed
    1. Zaina S., Perez‐Luque E. L., and Lund G., “Genetics Talks to Epigenetics? The Interplay Between Sequence Variants and Chromatin Structure,” Current Genomics 11, no. 5 (2010): 359–367, 10.2174/138920210791616662. - DOI - PMC - PubMed
    1. Collins A., Lonjou C., and Morton N. E., “Genetic Epidemiology of Single‐Nucleotide Polymorphisms,” Proceedings of the National Academy of Sciences of the United States of America 96, no. 26 (1999): 15173–15177, 10.1073/pnas.96.26.15173. - DOI - PMC - PubMed
    1. “Single Nucleotide Polymorphism—An Overview, ScienceDirect Topics,” accessed November 1, 2024, https://www.sciencedirect.com/topics/agricultural‐and‐biological‐science....
    1. “Genomic Markers and Personalized Medicine in Androgenetic Alopecia: A Comprehensive Review,” accessed November 1, 2024, https://www.mdpi.com/2079‐9284/11/5/148.

Substances